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PMID:1466622

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Citation

Rasmussen, LH, Jensen, LT, Avnstorp, C, Karlsmark, T, Peters, K and Hørslev-Petersen, K (1992) Collagen types I and III propeptides as markers of healing in chronic leg ulcers. A noninvasive method for the determination of procollagen propeptides in wound fluid--influence of growth hormone. Ann. Surg. 216:684-91

Abstract

A noninvasive method allowing measurements of the propeptides of collagen type III (PIIINP) and type I (PICP) in ulcer washings was developed. The response to topical human growth hormone was examined. Fourteen patients with venous ulcers were treated sequentially with human growth hormone (0.1, 0.25, and 1 IU/cm2/day), each dose for 1 week, followed by 1 week washout. On alternate days, three and two times during treatment and washout periods, respectively, the ulcers were washed and incubated for 30 minutes with sterile water. No changes in healing rates in relation to growth hormone application were observed. In contrast, PIIINP increased significantly to 168% (154% to 184%) (mean, 95% confidence interval) and 195% (179% to 218%) 5 and 9 days, respectively, after start of treatment, (p < 0.01). Propeptides of collagen type I reached a significant increase, to 196% (172% to 232%), in the fourth week, (p < 0.01). The areas under the curves of PICP and PIIINP correlated significantly with the healing rates (r = 0.57, p = 0.04; and r = 0.64, p = 0.01, respectively). The authors conclude that propeptide measurements may be useful markers of healing in clinical studies.

Links

PubMed PMC1242716

Keywords

Administration, Topical; Adult; Aged; Aged, 80 and over; Biological Markers/analysis; Chronic Disease; Exudates and Transudates/chemistry; Female; Growth Hormone/administration & dosage; Humans; Leg Ulcer/diagnosis; Leg Ulcer/therapy; Male; Middle Aged; Peptide Fragments/analysis; Procollagen/analysis; Wound Healing

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:CO3A1

involved_in

GO:0042060: wound healing

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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