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PMID:14614817
| Citation |
Han, Z, Saam, JR, Adams, HP, Mango, SE and Schumacher, JM (2003) The C. elegans Tousled-like kinase (TLK-1) has an essential role in transcription. Curr. Biol. 13:1921-9 |
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| Abstract |
The Tousled kinases comprise an evolutionarily conserved family of proteins that have been previously implicated in chromatin remodeling, DNA replication, and DNA repair. Here, we used RNA mediated interference (RNAi) to determine the function of the C. elegans Tousled kinase (TLK-1) during embryonic development. |
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| Keywords |
Animals; Base Sequence; Blotting, Western; Caenorhabditis elegans/embryology; Caenorhabditis elegans/enzymology; Caenorhabditis elegans Proteins; Chromatin/enzymology; Genes, Regulator/genetics; Histones/genetics; Immunohistochemistry; Methylation; Methyltransferases/genetics; Molecular Sequence Data; Phosphorylation; Phosphotransferases/genetics; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/physiology; RNA Interference; RNA Polymerase II/genetics; Sequence Analysis, DNA; Transcription, Genetic/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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