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PMID:14507999

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Citation

Lu, H, Rate, DN, Song, JT and Greenberg, JT (2003) ACD6, a novel ankyrin protein, is a regulator and an effector of salicylic acid signaling in the Arabidopsis defense response. Plant Cell 15:2408-20

Abstract

The previously reported Arabidopsis dominant gain-of-function mutant accelerated cell death6-1 (acd6-1) shows spontaneous cell death and increased disease resistance. acd6-1 also confers increased responsiveness to the major defense signal salicylic acid (SA). To further explore the role of ACD6 in the defense response, we cloned and characterized the gene. ACD6 encodes a novel protein with putative ankyrin and transmembrane regions. It is a member of one of the largest uncharacterized gene families in higher plants. Steady state basal expression of ACD6 mRNA required light, SA, and an intact SA signaling pathway. Additionally, ACD6 mRNA levels were increased in the systemic, uninfected tissue of Pseudomonas syringae-infected plants as well as in plants treated with the SA agonist benzothiazole (BTH). A newly isolated ACD6 loss-of-function mutant was less responsive to BTH and upon P. syringae infection had reduced SA levels and increased susceptibility. Conversely, plants overexpressing ACD6 showed modestly increased SA levels, increased resistance to P. syringae, and BTH-inducible and/or a low level of spontaneous cell death. Thus, ACD6 is a necessary and dose-dependent activator of the defense response against virulent bacteria and can activate SA-dependent cell death.

Links

PubMed PMC197305 Online version:10.1105/tpc.015412

Keywords

Ankyrins/genetics; Ankyrins/physiology; Arabidopsis Proteins/genetics; Arabidopsis Proteins/physiology; Base Sequence; DNA Primers; Immunity, Innate; Molecular Sequence Data; Plant Diseases/microbiology; Salicylic Acid/pharmacology; Signal Transduction/drug effects; Transformation, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ARATH:ACD6

involved_in

GO:0009751: response to salicylic acid

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:ACD6

involved_in

GO:0009617: response to bacterium

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:ACD6

involved_in

GO:0009416: response to light stimulus

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:ACD6

involved_in

GO:2000031: regulation of salicylic acid mediated signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:ACD6

involved_in

GO:1900426: positive regulation of defense response to bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:ACD6

located_in

GO:0016020: membrane

ECO:0000250: sequence similarity evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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