PMID:1359540

Citation	Ultsch, A, Schuster, CM, Laube, B, Schloss, P, Schmitt, B and Betz, H (1992) Glutamate receptors of Drosophila melanogaster: cloning of a kainate-selective subunit expressed in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 89:10484-8
Abstract	We report the isolation and functional characterization of cDNAs encoding a Drosophila kainate-selective glutamate receptor. The deduced mature 964-residue protein (DGluR-I) is 108,482 Da and exhibits significant homology to mammalian glutamate receptor subunits. Injection of DGluR-I cRNA into Xenopus oocytes generated kainate-operated ion channels which were blocked by the selective non-N-methyl-D-aspartate receptor antagonist 6-cyano-7-nitro-quinoxaline-2,3-dione and philanthotoxin. DGluR-I transcripts are differentially expressed during Drosophila development and, in late embryogenesis, accumulate in the central nervous system.
Links	PubMed PMC50363
Keywords	6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA/genetics; DNA/isolation & purification; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Kainic Acid/metabolism; Kainic Acid/pharmacology; Macromolecular Substances; Molecular Sequence Data; Nervous System/metabolism; Oligodeoxyribonucleotides; Oocytes/drug effects; Oocytes/physiology; Phenols/pharmacology; Polyamines/pharmacology; Polymerase Chain Reaction/methods; Quinoxalines/pharmacology; Receptors, Glutamate/drug effects; Receptors, Glutamate/genetics; Receptors, Glutamate/metabolism; Restriction Mapping; Sequence Homology, Amino Acid; Transcription, Genetic; Wasp Venoms/pharmacology; Xenopus
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