GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:12893879

From GONUTS
Jump to: navigation, search
Citation

Burri, L, Varlamov, O, Doege, CA, Hofmann, K, Beilharz, T, Rothman, JE, Söllner, TH and Lithgow, T (2003) A SNARE required for retrograde transport to the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 100:9873-7

Abstract

SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are central components of the machinery mediating membrane fusion in all eukaryotic cells. Sequence analysis of the yeast genome revealed a previously uncharacterized SNARE, SNARE-like tail-anchored protein 1 (Slt1). Slt1 is an essential protein localized in the endoplasmic reticulum (ER). It forms a SNARE complex with Sec22 and the ER syntaxin Ufe1. Down-regulation of Slt1 levels leads to improper secretion of proteins normally resident in the ER. We suggest that Slt1 is a component of the SNAREpin required for retrograde traffic to the ER. Based on the previously reported association with Ufe1 and Sec22, Sec20 likely contributes the fourth SNARE to the SNAREpin.

Links

PubMed PMC187870 Online version:10.1073/pnas.1734000100

Keywords

Amino Acid Sequence; Biological Transport, Active; Endoplasmic Reticulum/metabolism; Genome, Fungal; Membrane Proteins/genetics; Membrane Proteins/metabolism; Molecular Sequence Data; Qc-SNARE Proteins; SNARE Proteins; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Sequence Homology, Amino Acid; Vesicular Transport Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

YEAST:SEC20

enables

GO:0005484: SNAP receptor activity

ECO:0000255: match to sequence model evidence used in manual assertion

F

Seeded From UniProt

complete

YEAST:SEC20

part_of

GO:0031201: SNARE complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

YEAST:USE1

located_in

GO:0071458: integral component of cytoplasmic side of endoplasmic reticulum membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

YEAST:USE1

involved_in

GO:0006890: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.