PMID:12869515

Citation	Moog-Lutz, C, Cavé-Riant, F, Guibal, FC, Breau, MA, Di Gioia, Y, Couraud, PO, Cayre, YE, Bourdoulous, S and Lutz, PG (2003) JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood 102:3371-8
Abstract	Retinoic acid induces clinical remission in acute promyelocytic leukemia (APL) by triggering differentiation of leukemia promyelocytes. Here, we have characterized a gene encoding a member of the immunoglobulin superfamily, among novel retinoic acid-induced genes identified in APL cells. This protein, which was named JAML (junctional adhesion molecule-like), contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail. JAML mRNA is expressed in hematopoietic tissues and is prominently expressed in granulocytes. The fact that JAML protein is localized at the cell plasma membrane in the areas of cell-cell contacts, whereas it is not detected at free cell borders, suggests that JAML is engaged in homophilic interactions. Furthermore, a conserved dimerization motif among JAM members was shown to be important for JAML localization at the cell membrane. Finally, exogenous expression of JAML in myeloid leukemia cells resulted in enhanced cell adhesion to endothelial cells. Altogether, our results point to JAML as a novel member of the JAM family expressed on leukocytes with a possible role in leukocyte transmigration.
Links	PubMed Online version:10.1182/blood-2002-11-3462
Keywords	Base Sequence; Cell Adhesion/drug effects; Cell Adhesion Molecules/biosynthesis; Cell Adhesion Molecules/genetics; Cell Differentiation/genetics; Cell Line, Tumor; Endothelium, Vascular/cytology; Gene Expression Regulation/drug effects; Humans; Junctional Adhesion Molecules; Leukemia, Myeloid/metabolism; Leukemia, Myeloid/pathology; Leukocytes/cytology; Leukocytes/metabolism; Molecular Sequence Data; RNA, Messenger/biosynthesis; Sequence Analysis; Tretinoin/pharmacology; Tumor Cells, Cultured
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:ITB1	part_of	GO:0005886: plasma membrane	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
HUMAN:ITB1	enables	GO:0050839: cell adhesion molecule binding	ECO:0000353: physical interaction evidence used in manual assertion	UniProtKB:Q86YT9	F		Seeded From UniProt	complete
HUMAN:ITA4	involved_in	GO:0090074: negative regulation of protein homodimerization activity	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:ITA4	part_of	GO:0005886: plasma membrane	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
HUMAN:ITA4	enables	GO:0050839: cell adhesion molecule binding	ECO:0000353: physical interaction evidence used in manual assertion	UniProtKB:P78310	F		Seeded From UniProt	complete
HUMAN:JAML	enables	GO:0042803: protein homodimerization activity	ECO:0000314: direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
HUMAN:JAML	involved_in	GO:0007157: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:JAML	part_of	GO:0005886: plasma membrane	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
HUMAN:JAML	enables	GO:0050839: cell adhesion molecule binding	ECO:0000353: physical interaction evidence used in manual assertion	UniProtKB:P78310	F		Seeded From UniProt	complete
HUMAN:JAML	enables	GO:0005178: integrin binding	ECO:0000353: physical interaction evidence used in manual assertion	UniProtKB:P05556	F		Seeded From UniProt	complete
HUMAN:CXAR	enables	GO:0005178: integrin binding	ECO:0000353: physical interaction evidence used in manual assertion	UniProtKB:P13612	F		Seeded From UniProt	complete
HUMAN:CXAR	involved_in	GO:0007157: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:CXAR	enables	GO:0050839: cell adhesion molecule binding	ECO:0000353: physical interaction evidence used in manual assertion	UniProtKB:Q86YT9	F		Seeded From UniProt	complete

References

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