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PMID:12869515

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Citation

Moog-Lutz, C, Cavé-Riant, F, Guibal, FC, Breau, MA, Di Gioia, Y, Couraud, PO, Cayre, YE, Bourdoulous, S and Lutz, PG (2003) JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood 102:3371-8

Abstract

Retinoic acid induces clinical remission in acute promyelocytic leukemia (APL) by triggering differentiation of leukemia promyelocytes. Here, we have characterized a gene encoding a member of the immunoglobulin superfamily, among novel retinoic acid-induced genes identified in APL cells. This protein, which was named JAML (junctional adhesion molecule-like), contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail. JAML mRNA is expressed in hematopoietic tissues and is prominently expressed in granulocytes. The fact that JAML protein is localized at the cell plasma membrane in the areas of cell-cell contacts, whereas it is not detected at free cell borders, suggests that JAML is engaged in homophilic interactions. Furthermore, a conserved dimerization motif among JAM members was shown to be important for JAML localization at the cell membrane. Finally, exogenous expression of JAML in myeloid leukemia cells resulted in enhanced cell adhesion to endothelial cells. Altogether, our results point to JAML as a novel member of the JAM family expressed on leukocytes with a possible role in leukocyte transmigration.

Links

PubMed Online version:10.1182/blood-2002-11-3462

Keywords

Base Sequence; Cell Adhesion/drug effects; Cell Adhesion Molecules/biosynthesis; Cell Adhesion Molecules/genetics; Cell Differentiation/genetics; Cell Line, Tumor; Endothelium, Vascular/cytology; Gene Expression Regulation/drug effects; Humans; Junctional Adhesion Molecules; Leukemia, Myeloid/metabolism; Leukemia, Myeloid/pathology; Leukocytes/cytology; Leukocytes/metabolism; Molecular Sequence Data; RNA, Messenger/biosynthesis; Sequence Analysis; Tretinoin/pharmacology; Tumor Cells, Cultured

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ITB1

part_of

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:ITB1

enables

GO:0050839: cell adhesion molecule binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q86YT9

F

Seeded From UniProt

complete

HUMAN:ITA4

involved_in

GO:0090074: negative regulation of protein homodimerization activity

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ITA4

part_of

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:ITA4

enables

GO:0050839: cell adhesion molecule binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P78310

F

Seeded From UniProt

complete

HUMAN:JAML

enables

GO:0042803: protein homodimerization activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:JAML

involved_in

GO:0007157: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:JAML

part_of

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:JAML

enables

GO:0050839: cell adhesion molecule binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P78310

F

Seeded From UniProt

complete

HUMAN:JAML

enables

GO:0005178: integrin binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P05556

F

Seeded From UniProt

complete

HUMAN:CXAR

enables

GO:0005178: integrin binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P13612

F

Seeded From UniProt

complete

HUMAN:CXAR

involved_in

GO:0007157: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:CXAR

enables

GO:0050839: cell adhesion molecule binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q86YT9

F

Seeded From UniProt

complete

Notes

See also

References

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