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PMID:12860355

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Citation

Joyce, PR, Rogers, GR, Miller, AL, Mulder, RT, Luty, SE and Kennedy, MA (2003) Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders. Psychiatry Res 119:1-10

Abstract

We investigated whether polymorphisms of the dopamine D4 receptor (DRD4) and polymorphisms of the dopamine D3 receptor (DRD3) were associated with personality disorder symptomatology rather than with personality traits such as novelty seeking. DNA was obtained from 145 depressed patients in a clinical trial. These patients were assessed for the presence of personality disorder symptoms and disorders. The 2-repeat allele of the DRD4 exon III polymorphism was associated with increased rates of avoidant and obsessive personality disorder symptomatology. The T,T genotype of the DRD4 -521 C>T polymorphism was also associated with increased rates of avoidant and obsessive personality disorder symptomatology. The Gly9,Gly9 genotype of the DRD3 Ser9Gly polymorphism was associated with increased rates of obsessive personality disorder symptomatology. None of these three polymorphisms were associated with novelty seeking or other temperament traits on the Temperament and Character Inventory. Our results suggest that genetic polymorphisms of DRD4 and DRD3 may well be associated with personality traits, and that conflicting findings to date may arise from the problem of phenotype definition.

Links

PubMed

Keywords

Adult; Alleles; Character; Exons/genetics; Exploratory Behavior/physiology; Female; Fluoxetine/administration & dosage; Fluoxetine/therapeutic use; Genotype; Humans; Male; Nortriptyline/administration & dosage; Nortriptyline/therapeutic use; Obsessive-Compulsive Disorder/drug therapy; Obsessive-Compulsive Disorder/genetics; Personality Disorders/drug therapy; Personality Disorders/genetics; Polymerase Chain Reaction; Polymorphism, Genetic/genetics; Receptors, Dopamine D2/genetics; Receptors, Dopamine D3; Receptors, Dopamine D4; Risk Factors; Serotonin Uptake Inhibitors/administration & dosage; Serotonin Uptake Inhibitors/therapeutic use; Temperament; Trinucleotide Repeats/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:DRD3

involved_in

GO:0035176: social behavior

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:DRD4

involved_in

GO:0001662: behavioral fear response

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete


See also

References

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