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PMID:12791275

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Citation

Dai, P, Akimaru, H and Ishii, S (2003) A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci. Dev. Cell 4:917-28

Abstract

Transcription factor Ci mediates Hedgehog (Hh) signaling to determine the anterior/posterior (A/P) compartment of Drosophila wing disc. While Hh-inducible genes are expressed in A compartment cells abutting the A/P border, it is unclear how the boundaries of this region are established. Here, we have identified a Ci binding protein, Debra, that is expressed at relatively high levels in the band abutting the border of the Hh-responsive A compartment region. Debra mediates the polyubiquitination of full-length Ci, which then leads to its lysosomal degradation. Debra is localized in the multivesicular body, suggesting that the polyubiquitination of Ci directs its sorting into lysosome. Thus, Debra defines the border of the Hh-responsive region in the A compartment by inducing the lysosomal degradation of Ci.

Links

PubMed

Keywords

Animals; Carrier Proteins/metabolism; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins/metabolism; Down-Regulation; Drosophila/embryology; Drosophila/genetics; Drosophila Proteins; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/physiology; Gene Deletion; Gene Expression Regulation, Developmental; Hedgehog Proteins; Lysosomes/metabolism; Models, Biological; Morphogenesis; Mutation; Phosphorylation; Protein-Serine-Threonine Kinases/metabolism; Transcription Factors/metabolism; Transport Vesicles/metabolism; Ubiquitins/physiology; Wing/cytology; Wing/embryology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q961T5

located_in

GO:0005771: multivesicular body

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q9V474

located_in

GO:0005771: multivesicular body

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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