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PMID:12771515

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Citation

Graf, R, Klauser, S, Fukuoka, SI, Schiesser, M and Bimmler, D (2003) The bifunctional rat pancreatic secretory trypsin inhibitor/monitor peptide provides protection against premature activation of pancreatic juice. Pancreatology 3:195-206

Abstract

In the rat, two forms of the pancreatic secretory trypsin inhibitor, PSTI-I and PSTI-II, are secreted into pancreatic juice. It is assumed that their role is to protect the pancreas from premature activation of the protease-rich pancreatic juice. In the small intestine, PSTI-I, also called 'monitor peptide', is thought to have a different role: PSTI-I competes with protein for activated trypsin. In the presence of a protein-rich meal, free PSTI induces a release of cholecystokinine from the intestine.

Links

PubMed Online version:10.1159/000070729

Keywords

Animals; Binding Sites; Binding, Competitive; Cattle; Dose-Response Relationship, Drug; Drug Resistance; Endopeptidases/pharmacology; Intercellular Signaling Peptides and Proteins/administration & dosage; Intercellular Signaling Peptides and Proteins/metabolism; Intercellular Signaling Peptides and Proteins/pharmacology; Intercellular Signaling Peptides and Proteins/physiology; Male; Pancreas/metabolism; Pancreatic Juice/drug effects; Pancreatic Juice/physiology; Rats; Rats, Wistar; Receptors, Cell Surface/metabolism; Trypsin/pharmacology; Trypsin Inhibitors/pharmacology; Trypsinogen/drug effects; Trypsinogen/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:MMP13

involved_in

GO:1904244: positive regulation of pancreatic trypsinogen secretion

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ISK1

involved_in

GO:1900004: negative regulation of serine-type endopeptidase activity

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:ISK1

enables

GO:0004867: serine-type endopeptidase inhibitor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete


See also

References

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