PMID:12697064

Citation	Fang, R, Xiong, Y and Singleton, CK (2003) IfkA, a presumptive eIF2 alpha kinase of Dictyostelium, is required for proper timing of aggregation and regulation of mound size. BMC Dev. Biol. 3:3
Abstract	The transition from growth to development in Dictyostelium is initiated by amino acid starvation of growing amobae. In other eukaryotes, a key sensor of amino acid starvation and mediator of the resulting physiological responses is the GCN2 protein, an eIF2alpha kinase. GCN2 downregulates the initiation of translation of bulk mRNA and enhances translation of specific mRNAs by phosphorylating the translation initiation factor eIF2alpha. Two eIF2alpha kinases were identified in Dictyostelium and studied herein.
Links	PubMed PMC154100
Keywords	Amino Acid Sequence; Amino Acids/metabolism; Animals; Cell Line; Cyclic AMP/metabolism; Dictyostelium/enzymology; Dictyostelium/genetics; Dictyostelium/growth & development; Drosophila Proteins/chemistry; Drosophila Proteins/genetics; Gene Expression Regulation/genetics; Gene Expression Regulation/physiology; Gene Expression Regulation, Enzymologic/genetics; Gene Expression Regulation, Enzymologic/physiology; Molecular Sequence Data; Mutation/genetics; Phosphorylation; Protein Biosynthesis/genetics; Protein Kinases/genetics; Protein Kinases/physiology; Protein-Serine-Threonine Kinases; Protozoan Proteins/chemistry; Protozoan Proteins/genetics; Protozoan Proteins/physiology; RNA Stability/genetics; RNA, Messenger/biosynthesis; RNA, Protozoan/genetics; Saccharomyces cerevisiae Proteins/chemistry; Saccharomyces cerevisiae Proteins/genetics; Sequence Alignment; Transcription, Genetic/genetics; Transcription, Genetic/physiology; eIF-2 Kinase/biosynthesis; eIF-2 Kinase/chemistry; eIF-2 Kinase/genetics; eIF-2 Kinase/physiology
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