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PMID:12654300

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Citation

Merz, DC, Alves, G, Kawano, T, Zheng, H and Culotti, JG (2003) UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling. Dev. Biol. 256:173-86

Abstract

The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan. Viable alleles reduce the abundance of UNC-52 in late larval stages and increase the frequency of distal tip cell (DTC) migration defects caused by mutations disrupting the UNC-6/netrin guidance system. These unc-52 alleles do not cause circumferential DTC migration defects in an otherwise wild-type genetic background. The effects of unc-52 mutations on DTC migrations are distinct from effects on myofilament organization and can be partially suppressed by mutations in several genes encoding growth factor-like molecules, including EGL-17/FGF, UNC-129/TGF-beta, DBL-1/TGF-beta, and EGL-20/WNT. We propose that UNC-52 serves dual roles in C. elegans larval development in the maintenance of muscle structure and the regulation of growth factor-like signaling pathways.

Links

PubMed

Keywords

Animals; Animals, Genetically Modified; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Cell Movement/genetics; Disorders of Sex Development; Female; Genes, Helminth; Gonads/cytology; Gonads/growth & development; Gonads/metabolism; Growth Substances/genetics; Growth Substances/metabolism; Helminth Proteins/genetics; Helminth Proteins/metabolism; Larva/cytology; Larva/growth & development; Larva/metabolism; Male; Membrane Proteins; Muscles/metabolism; Mutation; Nerve Tissue Proteins; Phenotype; Protein Tyrosine Phosphatases/genetics; Proteoglycans/genetics; Proteoglycans/metabolism; Receptor-Like Protein Tyrosine Phosphatases; Receptors, Cell Surface/genetics; Receptors, Fibroblast Growth Factor/genetics; Signal Transduction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:G1K109

involved_in

GO:0016477: cell migration

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006745

P

Seeded From UniProt

complete

CAEEL:G1K109

involved_in

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001185

P

Seeded From UniProt

complete

CAEEL:G5EEI5

involved_in

GO:0016477: cell migration

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006745

P

Seeded From UniProt

complete

CAEEL:G5EEI5

involved_in

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001185

P

Seeded From UniProt

complete

CAEEL:H9G348

involved_in

GO:0016477: cell migration

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006745

P

Seeded From UniProt

complete

CAEEL:H9G348

involved_in

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001185

P

Seeded From UniProt

complete

CAEEL:H9G349

involved_in

GO:0016477: cell migration

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006745

P

Seeded From UniProt

complete

CAEEL:H9G349

involved_in

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001185

P

Seeded From UniProt

complete

CAEEL:H9G350

involved_in

GO:0016477: cell migration

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006745

P

Seeded From UniProt

complete

CAEEL:H9G350

involved_in

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001185

P

Seeded From UniProt

complete

CAEEL:H9G351

involved_in

GO:0016477: cell migration

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006745

P

Seeded From UniProt

complete

CAEEL:H9G351

involved_in

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001185

P

Seeded From UniProt

complete

CAEEL:H9G352

involved_in

GO:0016477: cell migration

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006745

P

Seeded From UniProt

complete

CAEEL:H9G352

involved_in

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001185

P

Seeded From UniProt

complete

CAEEL:H9G353

involved_in

GO:0016477: cell migration

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006745

P

Seeded From UniProt

complete

CAEEL:H9G353

involved_in

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001185

P

Seeded From UniProt

complete

CAEEL:H9G354

involved_in

GO:0016477: cell migration

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006745

P

Seeded From UniProt

complete

CAEEL:H9G354

involved_in

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001185

P

Seeded From UniProt

complete

CAEEL:UNC52

involved_in

GO:0016477: cell migration

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006745

P

Seeded From UniProt

complete

CAEEL:UNC52

involved_in

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001185

P

Seeded From UniProt

complete


See also

References

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