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PMID:12565827

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Citation

Edamatsu, M and Toyoshima, YY (2003) Fission yeast synaptobrevin is involved in cytokinesis and cell elongation. Biochem. Biophys. Res. Commun. 301:641-5

Abstract

Synaptobrevin is a vesicle-associated membrane protein playing an essential role in regulated vesicle transport. In this study, we characterized Syb1, synaptobrevin of Schizosaccharomyces pombe. Syb1 was located on various sizes of vesicle-like structures in the cytoplasm and enriched in the medial region and cell ends. Transport of Syb1 to the medial region was mainly dependent on F-actin and Myo52/Myo4. Syb1 is essential for cell viability and most of the syb1-null cells showed a round or short cylindrical form. These results suggest that Syb1 is involved in membrane trafficking of cytokinesis and cell elongation.

Links

PubMed

Keywords

Amino Acid Sequence; Cell Division; Cell Size; Cytoplasmic Vesicles/chemistry; Membrane Proteins/analysis; Membrane Proteins/chemistry; Membrane Proteins/physiology; Molecular Sequence Data; Protein Structure, Tertiary; R-SNARE Proteins; Schizosaccharomyces/chemistry; Schizosaccharomyces/cytology; Schizosaccharomyces pombe Proteins/analysis; Schizosaccharomyces pombe Proteins/chemistry; Schizosaccharomyces pombe Proteins/physiology; Sequence Homology, Amino Acid

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

SCHPO:SYB1

is_active_in

GO:0051285: cell cortex of cell tip

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

SCHPO:SYB1

is_active_in

GO:0031097: medial cortex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

SCHPO:SYB1

involved_in

GO:0016192: vesicle-mediated transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

SCHPO:SYB1

part_of

GO:0030659: cytoplasmic vesicle membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

SCHPO:SYB1

part_of

GO:0032153: cell division site

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

SCHPO:SYB1

part_of

GO:0051285: cell cortex of cell tip

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

Notes

See also

References

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