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PMID:12563289
| Citation |
Jacinto, E and Hall, MN (2003) Tor signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell Biol. 4:117-26 |
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| Abstract |
TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors. |
| Links |
PubMed Online version:10.1038/nrm1018 |
| Keywords |
Animals; Drosophila Proteins/physiology; Drosophila melanogaster; Humans; Phosphatidylinositol 3-Kinases/physiology; Phosphotransferases (Alcohol Group Acceptor)/physiology; Receptor Protein-Tyrosine Kinases/physiology; Saccharomyces cerevisiae Proteins/physiology; Signal Transduction; Tacrolimus Binding Protein 1A/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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