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PMID:12452830

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Citation

Gjertsson, I, Hultgren, OH and Tarkowski, A (2002) Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance. Clin. Exp. Immunol. 130:409-14

Abstract

Staphyllococcus aureus-induced infections often result in high mortality and permanent joint destruction, despite treatment with antibiotics. IL-10 is typically regarded as an anti-inflammatory cytokine because it promotes a T helper cell type 2 response, and subsequently down-regulates cell mediated immune functions. To investigate the role of IL-10 in S. aureus-induced arthritis and sepsis, Balb/c mice, intact or defective with respect to IL-10 gene were intravenously inoculated with bacteria. IL-10-/- mice develop a more frequent and destructive arthritis compared to their congeneic controls. The mechanisms regulating such outcome may be due not only to the anti-inflammatory properties of IL-10 but also, directly or indirectly, to antibacterial features of this molecule. Indeed, inoculation of staphylococci to IL-10-/- mice resulted in higher bacterial load in blood and kidneys compared to congeneic controls. Altogether our data indicate that IL-10 is essential for efficient elimination of bacteria and thereby for protection against septic arthritis.

Links

PubMed PMC1906560

Keywords

Animals; Arthritis, Experimental/immunology; Arthritis, Experimental/microbiology; Arthritis, Infectious/immunology; Arthritis, Infectious/microbiology; Cytokines/immunology; Female; Interleukin-10/genetics; Interleukin-10/immunology; Macrophages, Peritoneal/immunology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phagocytosis; Staphylococcal Infections/immunology; Statistics, Nonparametric

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:IL10

involved_in

GO:0002439: chronic inflammatory response to antigenic stimulus

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857199

P

Seeded From UniProt

complete

MOUSE:IL10

involved_in

GO:0002875: negative regulation of chronic inflammatory response to antigenic stimulus

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857199

P

Seeded From UniProt

complete

MOUSE:IL10

involved_in

GO:0032689: negative regulation of interferon-gamma production

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857199

P

Seeded From UniProt

complete

MOUSE:IL10

involved_in

GO:0032720: negative regulation of tumor necrosis factor production

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857199

P

Seeded From UniProt

complete


See also

References

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