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PMID:12386929

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Citation

Damen, WG (2002) fushi tarazu: a Hox gene changes its role. Bioessays 24:992-5

Abstract

The Hox genes play a role in anteroposterior axis specification of bilaterian animals that has been conserved for more than 600 million years. However, some of these genes have occasionally changed their roles in evolution. For example, the insect gene fushi tarazu (ftz), although localised in the Hox cluster, no longer acts as a Hox gene, but is involved in segmentation and nervous system development. Recent data of Mouchel-Vielh et al., and Hughes and Kaufman on ftz homologues in a crustacean and a myriapod, respectively, shed new light onto the evolution of this gene.

Links

PubMed Online version:10.1002/bies.10180

Keywords

Animals; Body Patterning/genetics; Central Nervous System/growth & development; Central Nervous System/physiology; Evolution, Molecular; Fushi Tarazu Transcription Factors; Gene Expression Regulation, Developmental; Genes, Insect; Homeodomain Proteins/genetics; Multigene Family

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:FTZ

involved_in

GO:0001708: cell fate specification

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:FTZ

involved_in

GO:0007417: central nervous system development

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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