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PMID:12383972

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Citation

Liu, HL, Cao, R, Jin, L and Chen, LW (2002) Immunocytochemical localization of substance P receptor in hypothalamic oxytocin-containing neurons of C57 mice. Brain Res. 948:175-9

Abstract

With the use of double immunofluorescence, we have examined the distribution of oxytocin-containing neurons that express substance P receptor (SPR) in the hypothalamus of C57 mice. The distribution of oxytocin-like immunoreactive neurons overlapped with that of SPR-like immunoreactive neurons in the paraventricular nucleus and supraoptic nucleus of the hypothalamus. Neurons showing both oxytocin- and SPR-like immunoreactivities were predominantly found in both nuclei. A few neurons that were double-labeled with oxytocin- and SPR-like immunoreactivities were also scattered in the hypothalamic periventricular and preoptic regions. Semi-quantitative analysis indicated that about 94% of the oxytocin-like neurons displayed SPR-like immunoreactivity. These double-labeled cells constituted about 91% of the SPR-like neurons in the aforementioned regions. The present study provides morphological evidence for tachykinin-induced modulation of oxytocin-containing neurons as mediated by substance P receptor in the hypothalamus of mammals.

Links

PubMed

Keywords

Animals; Hypothalamus/cytology; Hypothalamus/metabolism; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Neurons/cytology; Neurons/metabolism; Oxytocin/biosynthesis; Paraventricular Hypothalamic Nucleus/cytology; Paraventricular Hypothalamic Nucleus/metabolism; Receptors, Neurokinin-1/biosynthesis; Supraoptic Nucleus/cytology; Supraoptic Nucleus/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:NK1R

located_in

GO:0071944: cell periphery

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000540)

Seeded From UniProt

complete

MOUSE:NEU1

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000540)

Seeded From UniProt

complete

MOUSE:NK1R

part_of

GO:0071944: cell periphery

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(CL:0000540)

Seeded From UniProt

complete

MOUSE:NEU1

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(CL:0000540)

Seeded From UniProt

complete


See also

References

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