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PMID:12379863

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Citation

Hallam, SJ, Goncharov, A, McEwen, J, Baran, R and Jin, Y (2002) SYD-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains, specifies axon identity in C. elegans. Nat. Neurosci. 5:1137-46

Abstract

Axons are defined by the presence of presynaptic specializations at specific locations. We show here that loss-of-function mutations in the C. elegans gene syd-1 cause presynaptic specializations to form in the dendritic processes of GABA-expressing motor neurons during initial differentiation. At a later developmental stage, however, syd-1 is not required for the polarity respecification of a subset of these neurons. The SYD-1 protein contains PDZ, C2 and rho-GTPase activating protein (GAP)-like domains, and is localized to presynaptic terminals in mature neurons. A truncated SYD-1 that lacks the rhoGAP domain interferes with neurite outgrowth and guidance. Our data indicate that syd-1 may be involved in specifying axon identity during initial polarity acquisition.

Links

PubMed Online version:10.1038/nn959

Keywords

Animals; Axons/chemistry; Axons/physiology; Caenorhabditis elegans; Caenorhabditis elegans Proteins/chemistry; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; GTPase-Activating Proteins/chemistry; Gene Expression Regulation, Developmental; Larva; Molecular Sequence Data; Mutation, Missense/physiology; Neurites/chemistry; Neurites/physiology; Neurons/physiology; Presynaptic Terminals/chemistry; Presynaptic Terminals/physiology; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Spinal Cord/cytology; Spinal Cord/embryology

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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