GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:12361962

From GONUTS
Jump to: navigation, search
Citation

Rubin, BP, Tucker, RP, Brown-Luedi, M, Martin, D and Chiquet-Ehrismann, R (2002) Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro. Development 129:4697-705

Abstract

The transmembrane glycoprotein teneurin 2 is expressed by neurons in the developing avian thalamofugal visual system at periods that correspond with target recognition and synaptogenesis. Partial and full-length teneurin 2 constructs were expressed in cell lines in vitro. Expression of the cytoplasmic domain is required for the induction of filopodia, the transport of teneurin 2 into neurites and the co-localization of teneurin 2 with the cortical actin cytoskeleton. In addition, expression of the extracellular domain of teneurin 2 by HT1080 cells induced cell aggregation, and the extracellular domain of teneurin 2 became concentrated at sites of cell-cell contact in neuroblastoma cells. These observations indicate that the homophilic binding of teneurin 2 may play a role in the development of specific neuronal circuits in the developing visual system.

Links

PubMed

Keywords

Animals; Avian Proteins; Axons/metabolism; Cell Adhesion/physiology; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Chick Embryo; Cricetinae; Cytoplasm/metabolism; Extracellular Matrix/metabolism; Gene Expression Regulation, Developmental; Humans; Membrane Proteins/genetics; Membrane Proteins/metabolism; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neurites/metabolism; Neuroblastoma/pathology; Protein Structure, Tertiary; Protein Transport; Thalamus/embryology; Thalamus/metabolism; Visual Pathways/embryology; Visual Pathways/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CHICK:TEN2

located_in

GO:0030054: cell junction

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:TEN2

located_in

GO:0030426: growth cone

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:TEN2

located_in

GO:0030175: filopodium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:TEN2

located_in

GO:0030425: dendrite

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:TEN2

part_of

GO:0030426: growth cone

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:TEN2

part_of

GO:0030425: dendrite

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:TEN2

part_of

GO:0030175: filopodium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:TEN2

part_of

GO:0030054: cell junction

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:TEN2

involved_in

GO:0098609: cell-cell adhesion

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

See Help:References for how to manage references in GONUTS.