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PMID:12220705

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Citation

Zhang, K, Davids, E, Tarazi, FI and Baldessarini, RJ (2002) Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity. Brain Res. Dev. Brain Res. 137:135-8

Abstract

We examined serotonin (5-HT) transporters in rat forebrain using quantitative autoradiography at three distinct developmental stages after neonatal 6-hydroxydopamine lesions. The lesions substantially increased 5-HT transporter binding in both caudate-putamen and nucleus accumbens, but not cerebral cortex. The effects reached maximal levels as early as postnatal day (PD) 24, and were sustained until early adulthood. Behavioral analyses indicated that neonatal lesions resulted in motor hyperactivity on PD 24, but not on PD 36 or 59. These findings suggest that excess 5-HT transporters reflect serotonin hyperinnervation reported to occur in lesioned rats, and may modulate motor hyperactivity.

Links

PubMed

Keywords

Aging/metabolism; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity/metabolism; Attention Deficit Disorder with Hyperactivity/physiopathology; Carrier Proteins/metabolism; Disease Models, Animal; Female; Hyperkinesis/chemically induced; Hyperkinesis/metabolism; Hyperkinesis/physiopathology; Male; Membrane Glycoproteins/metabolism; Membrane Transport Proteins; Neostriatum/growth & development; Neostriatum/metabolism; Neostriatum/physiopathology; Nerve Tissue Proteins; Neuronal Plasticity/physiology; Nucleus Accumbens/growth & development; Nucleus Accumbens/metabolism; Nucleus Accumbens/physiopathology; Oxidopamine/diagnostic use; Presynaptic Terminals/metabolism; Rats; Rats, Sprague-Dawley; Serotonin/metabolism; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission/physiology; Up-Regulation/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:SC6A4

involved_in

GO:0007626: locomotory behavior

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

RAT:SC6A4

involved_in

GO:0006837: serotonin transport

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

RAT:SC6A4

enables

GO:0005335: serotonin:sodium symporter activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

See also

References

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