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PMID:12163178

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Citation

Li, QH, Haga, I, Shimizu, T, Itoh, M, Kurosaki, T and Fujisawa, J (2002) Retardation of the G2-M phase progression on gene disruption of RNA binding protein Sam68 in the DT40 cell line. FEBS Lett. 525:145-50

Abstract

Sam68 is an RNA binding protein that is tyrosine-phosphorylated by Src during mitosis and has been postulated to have a role in cell cycle control by modulating RNA metabolism. To elucidate the function of this protein, we isolated a Sam68-deficient DT40 cell line by gene disruption. The Sam68-deficient cells exhibited markedly decreased growth and the growth retardation was due to elongation of the G2-M phase, however, the kinase activity associated with Cdc2 remained unaltered. Our results indicate that Sam68 may play a critical role in G2-M progression in a manner independent of the control of Cyclin/Cdc2 kinase activity.

Links

PubMed

Keywords

Animals; B-Lymphocytes/cytology; B-Lymphocytes/metabolism; CDC2 Protein Kinase/metabolism; Cell Division/genetics; Cell Division/physiology; Cell Line; Chickens; Clone Cells/cytology; Clone Cells/metabolism; Enzyme Activation/physiology; G2 Phase/physiology; Gene Targeting; Mitosis/physiology; Molecular Sequence Data; RNA-Binding Proteins/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CHICK:KHDR1

involved_in

GO:0000086: G2/M transition of mitotic cell cycle

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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