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PMID:12119094

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Citation

Calleja, M, Renaud, O, Usui, K, Pistillo, D, Morata, G and Simpson, P (2002) How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila. Gene 292:1-12

Abstract

The notum of Drosophila is a good model system for the study of two-dimensional pattern formation. Attention has mainly focused on the regulation of the spatial expression of the genes of the achaete-scute complex (AS-C) that results in a stereotyped bristle pattern. Expression of AS-C genes has traditionally been viewed as a consequence of the activity of a group of factors that constitute a prepattern [Stern, 1954. Am. Sci. 42, 213]. The prepattern is thought to be composed of a mosaic of transcription factors that act in combination, through discrete cis-regulatory sequences, to activate expression of genes of the AS-C in small clusters of cells at the sites of each future bristle. Recent results challenge this view and suggest a hierarchy of activity amongst prepattern genes. It is suggested that in the medial notum, the selector-like gene pannier regulates the entire pattern, and is the only factor to directly activate AS-C genes. Other factors may play subsidiary roles. On the lateral notum genes of the iroquois complex appear to regulate the lateral pattern. Regulation of pannier and iroquois depends upon the signalling molecule Decapentaplegic. The majority of genes are expressed in either longitudinal or transverse domains on the notum and we discuss the possibility that pattern formation may rely on these two axial coordinates. We also discuss preliminary results suggesting that prepattern factors also regulate genes required for other, little studied, aspects of notal morphology, such as the muscle attachment sites and pigment distribution. Thus there may be a common prepattern for the entire structure.

Links

PubMed

Keywords

Animals; Basic Helix-Loop-Helix Transcription Factors; Body Patterning/genetics; DNA-Binding Proteins/genetics; Drosophila/embryology; Drosophila/genetics; Drosophila/growth & development; Drosophila Proteins; Epithelium/embryology; Epithelium/growth & development; Gene Expression Regulation, Developmental; Transcription Factors/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A0A0B4KGW2

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:E1JIP0

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:O76858

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:AST5

involved_in

GO:0008407: chaeta morphogenesis

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

DROME:AST5

involved_in

GO:0006355: regulation of transcription, DNA-templated

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

DROME:AST4

involved_in

GO:0008407: chaeta morphogenesis

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

DROME:AST4

involved_in

GO:0006355: regulation of transcription, DNA-templated

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

DROME:APTE

involved_in

GO:0007476: imaginal disc-derived wing morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:APTE

involved_in

GO:0007450: dorsal/ventral pattern formation, imaginal disc

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:PNR

involved_in

GO:0045892: negative regulation of transcription, DNA-templated

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:PNR

involved_in

GO:0042440: pigment metabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q24163

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:ARA

involved_in

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

DROSP:Q26452

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7JP26

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IN91

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8SXA1

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9GSP4

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VDC6

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VED3

involved_in

GO:0042440: pigment metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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