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PMID:12054681
| Citation |
Rosati, O and Martin, MU (2002) Identification and characterization of murine IRAK-M. Biochem. Biophys. Res. Commun. 293:1472-7 |
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| Abstract |
Interleukin-1 receptor-associated-kinases (IRAKs) are signal transduction mediators of the Toll/IL-1 receptor family, which comprise several transmembrane proteins involved in host defense mechanisms. Today four different human IRAKs (hu-IRAK-1, hu-IRAK-2, hu-IRAK-M, hu-IRAK-4) and two murine IRAKs (mouse pelle like kinase (mPLK) and mu-IRAK-4) have been described. Here we report the identification and characterization of murine IRAK-M (mu-IRAK-M), a mouse homologue to human IRAK-M (hu-IRAK-M). These IRAK-M molecules show 71% sequence identity, a comparable cellular expression, and functional similarities with respect to signal transduction capacity and kinase activity, suggesting functional homology in signalling in human and mouse cells. |
| Links |
PubMed Online version:10.1016/S0006-291X(02)00411-4 |
| Keywords |
Animals; Blotting, Northern; Cells, Cultured; DNA, Complementary/metabolism; Genes, Reporter; Humans; Immunoblotting; Interleukin-1/metabolism; Interleukin-1 Receptor-Associated Kinases; Mice; NF-kappa B/metabolism; Phosphorylation; Polymerase Chain Reaction; Precipitin Tests; Protein Kinases/chemistry; Protein Kinases/metabolism; Protein Structure, Tertiary; RNA/metabolism; Recombinant Proteins/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tissue Distribution |
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Significance
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| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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