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PMID:11984530

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Citation

Ng, AY, Waring, P, Ristevski, S, Wang, C, Wilson, T, Pritchard, M, Hertzog, P and Kola, I (2002) Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium. Gastroenterology 122:1455-66

Abstract

The mammalian small intestine is lined by a highly specialized epithelium that functions in the digestion and absorption of nutrients. The molecular mechanisms that direct intestinal epithelial cell morphogenesis and terminal differentiation are poorly understood. We have previously identified Elf3 (E74-like factor-3) as a member of the ETS transcription factor family strongly expressed in small intestinal epithelium. The aim of this study is to investigate the biological roles of Elf3 in vivo.

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PubMed

Keywords

Animals; Apoptosis; Cell Differentiation; Cell Division; DNA-Binding Proteins; Extracellular Matrix/physiology; Intestinal Mucosa/embryology; Mice; Morphogenesis; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; Receptors, Transforming Growth Factor beta/genetics; Transcription Factors/genetics; Transcription Factors/physiology

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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