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PMID:11959138

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Citation

Sakata, Y, Saegusa, H, Zong, S, Osanai, M, Murakoshi, T, Shimizu, Y, Noda, T, Aso, T and Tanabe, T (2002) Ca(v)2.3 (alpha1E) Ca2+ channel participates in the control of sperm function. FEBS Lett. 516:229-33

Abstract

To know the function of the Ca2+ channel containing alpha(1)2.3 (alpha1E) subunit (Ca(v)2.3 channel) in spermatozoa, we analyzed Ca2+ transients and sperm motility using a mouse strain lacking Ca(v)2.3 channel. The averaged rising rates of Ca2+ transients induced by alpha-D-mannose-bovine serum albumin in the head region of Ca(v)2.3-/- sperm were significantly lower than those of Ca(v)2.3+/+ sperm. A computer-assisted sperm motility assay revealed that straight-line velocity and linearity were greater in Ca(v)2.3-/- sperm than those in Ca(v)2.3+/+ sperm. These results suggest that the Ca(v)2.3 channel plays some roles in Ca2+ transients and the control of flagellar movement.

Links

PubMed

Keywords

Animals; Calcium Channels/genetics; Calcium Channels/physiology; Calcium Channels, R-Type; Calcium Signaling/genetics; Calcium Signaling/physiology; Cation Transport Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Movement/physiology; Sperm Motility/genetics; Sperm Motility/physiology; Sperm Tail/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:CAC1E

enables

GO:0005245: voltage-gated calcium channel activity

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2179732

F

  • occurs_in:(CL:0000019)

Seeded From UniProt

complete

MOUSE:CAC1E

acts_upstream_of_or_within

GO:0030317: flagellated sperm motility

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2179732

P

Seeded From UniProt

complete

MOUSE:CAC1E

acts_upstream_of_or_within

GO:0070588: calcium ion transmembrane transport

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2179732

P

  • occurs_in:(CL:0000019)

Seeded From UniProt

complete


See also

References

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