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PMID:11877375

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Citation

Suzuki, G, Yanagawa, Y, Kwok, SF, Matsui, M and Deng, XW (2002) Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Genes Dev. 16:554-9

Abstract

A group of evolutionarily conserved pleiotropic COP/DET/FUS proteins was initially defined by their ability to repress photomorphogenesis in Arabidopsis. It was proposed that this regulation be mediated by targeting degradation of key cellular regulators that promote photomorphogenesis. Among them, COP1 and the COP9 signalosome have been hypothesized to fulfill the roles as an ubiquitin ligase (E3) and an essential E3 modulator. Here we report that COP10 encodes a protein similar to ubiquitin-conjugating enzyme (E2) variant proteins (UEV). COP10 is part of a nuclear protein complex and capable of directly interacting with both COP1 and the COP9 signalosome. Our data indicates that COP10 defines a possible E2 activity, thus validating the working hypothesis that the pleiotropic COP/DET/FUS group of proteins defined a protein ubiquitination pathway.

Links

PubMed PMC155353 Online version:10.1101/gad.964602

Keywords

Amino Acid Sequence; Arabidopsis/enzymology; Arabidopsis/genetics; Arabidopsis/radiation effects; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Carrier Proteins/metabolism; Ligases/genetics; Ligases/metabolism; Light; Models, Biological; Molecular Sequence Data; Morphogenesis; Multiprotein Complexes; Peptide Hydrolases/metabolism; Plant Proteins/metabolism; Proteasome Endopeptidase Complex; Proteins/metabolism; Repressor Proteins/metabolism; Sequence Homology, Amino Acid; Signal Transduction; Ubiquitin/metabolism; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ARATH:COP1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9LJD7

F

Seeded From UniProt

complete

ARATH:COP10

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

ARATH:COP10

enables

GO:0004842: ubiquitin-protein transferase activity

ECO:0000250: sequence similarity evidence used in manual assertion

F

Seeded From UniProt

complete

ARATH:COP10

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P43254

F

Seeded From UniProt

complete


See also

References

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