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PMID:11856370

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Citation

Kim, YC, Lee, MH, Ryu, SS, Kim, JH and Koo, HS (2002) Coaction of DNA topoisomerase IIIalpha and a RecQ homologue during the germ-line mitosis in Caenorhabditis elegans. Genes Cells 7:19-27

Abstract

Among the four RecQ homologues predicted from the Caenorhabditis elegans genomic DNA sequence, T04A11.6 is most similar to Bloom syndrome's protein in humans. To investigate a possible interaction of the protein with topoisomerase IIIalpha (TOP3alpha), as observed between TOP3 and RecQ homologues in yeast and human, the top3alpha gene expression was suppressed by RNA interference (RNAi) in the him-6(e1104) C. elegans strain which is mutated in T04A11.6 (F. Mueller & C. Wicky, personal communication).

Links

PubMed

Keywords

Adenosine Triphosphatases/metabolism; Animals; Caenorhabditis elegans/cytology; Caenorhabditis elegans/physiology; Chromosome Aberrations; DNA Helicases/metabolism; DNA Topoisomerases, Type I/metabolism; Germ Cells/physiology; Meiosis/physiology; Mitosis/physiology; Protein Binding; RNA/immunology; RNA/metabolism; RNA/physiology; RecQ Helicases

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:BLM

involved_in

GO:0000278: mitotic cell cycle

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006596

P

Seeded From UniProt

complete

CAEEL:BLM

enables

GO:0019899: enzyme binding

ECO:0000353: physical interaction evidence used in manual assertion

WB:WBGene00006596

F

Seeded From UniProt

complete

CAEEL:BLM

involved_in

GO:0007059: chromosome segregation

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006596

P

Seeded From UniProt

complete

CAEEL:BLM

involved_in

GO:0051321: meiotic cell cycle

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006596

P

Seeded From UniProt

complete

CAEEL:BLM

involved_in

GO:0051276: chromosome organization

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00006596

P

Seeded From UniProt

complete


See also

References

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