PMID:11807022

Citation	Kyriakopoulou, K, de Diego, I, Wassef, M and Karagogeos, D (2002) A combination of chain and neurophilic migration involving the adhesion molecule TAG-1 in the caudal medulla. Development 129:287-96
Abstract	Neuronal populations destined to form several precerebellar nuclei are generated by the rhombic lip in the caudal hindbrain. These immature neurons gather into the olivary and the superficial migratory streams and migrate tangentially around the hindbrain to reach their final position. We focus on the cells of the superficial stream that migrate ventrally, cross the midline and form the lateral reticular (LRN) and external cuneate (ECN) nuclei. The cells of the superficial steam are preceded by long leading processes; in the dorsal neural tube, they migrate in close apposition to each other and form distinct chains, whereas they disperse and follow Tuj-1 immunoreactive axons on reaching the ventral hindbrain. This suggests that, in the superficial stream, neuronal migration combines both homotypic and heterotypic mechanisms. We also show that the adhesion molecule TAG-1 is expressed by the migrating cells. Blocking TAG-1 function results in alterations in the superficial migration, indicating that TAG-1 is involved in the superficial migration. Other members of the immunoglobulin superfamily and known ligands of TAG-1 are also expressed in the region of the migration but are not involved in the migration. These findings provide evidence that the TAG-1 protein is involved as a contact-dependent signal guiding not only axonal outgrowth but also cell migration.
Links	PubMed
Keywords	Animals; Antibodies; Cell Adhesion Molecules, Neuronal/genetics; Cell Adhesion Molecules, Neuronal/immunology; Cell Adhesion Molecules, Neuronal/metabolism; Cell Movement; Contactin 2; Culture Techniques; Female; Immunohistochemistry; In Situ Hybridization; Male; Medulla Oblongata/cytology; Medulla Oblongata/embryology; Medulla Oblongata/physiology; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Neurons/cytology; Neurons/physiology; Pregnancy
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:CNTN2	acts_upstream_of_or_within	GO:0001764: neuron migration	ECO:0000315: mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16916) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete

References

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