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Jones, D, Crowe, E, Stevens, TA and Candido, EP (2002) Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Genome Biol. 3:RESEARCH0002
The eukaryotic ubiquitin-conjugation system sets the turnover rate of many proteins and includes activating enzymes (E1s), conjugating enzymes (UBCs/E2s), and ubiquitin-protein ligases (E3s), which are responsible for activation, covalent attachment and substrate recognition, respectively. There are also ubiquitin-like proteins with distinct functions, which require their own E1s and E2s for attachment. We describe the results of RNA interference (RNAi) experiments on the E1s, UBC/E2s and ubiquitin-like proteins in Caenorhabditis elegans. We also present a phylogenetic analysis of UBCs.
Amino Acid Sequence; Animals; Caenorhabditis elegans/enzymology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Embryo, Nonmammalian/drug effects; Embryo, Nonmammalian/metabolism; Embryonic Development; Isoenzymes/genetics; Isoenzymes/metabolism; Ligases/genetics; Ligases/metabolism; Molecular Sequence Data; Phylogeny; RNA, Double-Stranded/administration & dosage; RNA, Double-Stranded/genetics; RNA, Double-Stranded/physiology; Sequence Alignment; Sequence Homology, Amino Acid; Ubiquitins/genetics; Ubiquitins/metabolism
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