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PMID:11566099

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Citation

Sun, T, Echelard, Y, Lu, R, Yuk, DI, Kaing, S, Stiles, CD and Rowitch, DH (2001) Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr. Biol. 11:1413-20

Abstract

Organizing signals such as Sonic hedgehog are thought to specify neuronal subtype identity by regulating the expression of homeodomain proteins in progenitors of the embryonic neural tube. One of these, Nkx2.2, is necessary and sufficient for the development of V3 interneurons.

Links

PubMed

Keywords

Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Gene Expression; Helix-Loop-Helix Motifs; High Mobility Group Proteins/genetics; High Mobility Group Proteins/metabolism; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Mice; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neurons/cytology; Neurons/metabolism; SOXE Transcription Factors; Stem Cells/cytology; Stem Cells/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:NKX22

involved_in

GO:0048709: oligodendrocyte differentiation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1355331

P

Seeded From UniProt

complete

MOUSE:NKX22

involved_in

GO:0048714: positive regulation of oligodendrocyte differentiation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1355331

P

Seeded From UniProt

complete

MOUSE:OLIG2

involved_in

GO:0045665: negative regulation of neuron differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:OLIG2

involved_in

GO:0030182: neuron differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:OLIG2

involved_in

GO:0048709: oligodendrocyte differentiation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:97347

P

Seeded From UniProt

complete

MOUSE:OLIG2

involved_in

GO:0048714: positive regulation of oligodendrocyte differentiation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:97347

P

Seeded From UniProt

complete


See also

References

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