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PMID:11557891

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Citation

Freiman, RN, Albright, SR, Zheng, S, Sha, WC, Hammer, RE and Tjian, R (2001) Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Science 293:2084-7

Abstract

Transcription factor TFIID, composed of TBP and TAFII subunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary. Female mice lacking TAFII105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAFII105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient ovaries. Together, these studies suggest that TAFII105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAFII105 as a cell type-specific component of the mammalian transcriptional machinery.

Links

PubMed Online version:10.1126/science.1061935

Keywords

Animals; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Down-Regulation; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Granulosa Cells/metabolism; Granulosa Cells/physiology; In Situ Hybridization; Infertility, Female; Male; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Organ Size; Organ Specificity; Ovarian Follicle/growth & development; Ovary/cytology; Ovary/growth & development; Ovary/metabolism; Ovary/physiology; Ovulation; Protein Subunits; Signal Transduction; TATA-Binding Protein Associated Factors; Transcription Factor TFIID; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription Factors, TFII/metabolism; Transcription, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:A0A2I3BPN6

acts_upstream_of_or_within

GO:0001541: ovarian follicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2152347

P

Seeded From UniProt

complete

MOUSE:A0A2I3BPN6

acts_upstream_of_or_within

GO:0006366: transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:A0A2I3BPN6

acts_upstream_of_or_within

GO:0006351: transcription, DNA-templated

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:E9QAP7

acts_upstream_of_or_within

GO:0001541: ovarian follicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2152347

P

Seeded From UniProt

complete

MOUSE:E9QAP7

acts_upstream_of_or_within

GO:0006366: transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:E9QAP7

acts_upstream_of_or_within

GO:0006351: transcription, DNA-templated

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TAF4B

part_of

GO:0005667: transcription regulator complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

MOUSE:Q3UWM6

acts_upstream_of_or_within

GO:0001541: ovarian follicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2152347

P

Seeded From UniProt

complete

MOUSE:Q3UWM6

acts_upstream_of_or_within

GO:0006366: transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:Q3UWM6

acts_upstream_of_or_within

GO:0006351: transcription, DNA-templated

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:Q91WW6

acts_upstream_of_or_within

GO:0001541: ovarian follicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2152347

P

Seeded From UniProt

complete

MOUSE:Q91WW6

acts_upstream_of_or_within

GO:0006366: transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:Q91WW6

acts_upstream_of_or_within

GO:0006351: transcription, DNA-templated

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TAF4B

acts_upstream_of_or_within

GO:0006366: transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TAF4B

acts_upstream_of_or_within

GO:0006357: regulation of transcription by RNA polymerase II

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TAF4B

part_of

GO:0005667: transcription factor complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete


See also

References

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