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PMID:11493530

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Citation

Wada, AM, Reese, DE and Bader, DM (2001) Bves: prototype of a new class of cell adhesion molecules expressed during coronary artery development. Development 128:2085-93

Abstract

Bves is a protein expressed in cells of the developing coronary vascular system, specifically in the proepicardium, migrating epithelial epicardium, delaminated vasculogenic mesenchyme and vascular smooth muscle cells. Here, we show that Bves protein undergoes a dynamic subcellular redistribution during coronary vessel development. Bves is a membrane protein with three predicted transmembrane helices, an extracellular C terminus and an intracellular N terminus, and is confined to the lateral membrane compartment of epithelial cells. When epicardial cells are dissociated into single cells in vitro, Bves accumulates in a perinuclear region until cells make contact, at which time Bves is trafficked to the cell membrane. Bves accumulates at points of cell/cell contact, such as filopodia and cell borders, before the appearance of E-cadherin, suggesting an early role in cell adhesion. While Bves shares no homology with any known adhesion molecule, transfection of Bves into L-cells readily confers adhesive behavior to these cells. Finally, Bves antibodies inhibit epithelial migration of vasculogenic cells from the proepicardium. This study provides direct evidence that Bves is a novel cell adhesion molecule and suggests a role for Bves in coronary vasculogenesis.

Links

PubMed

Keywords

Animals; Avian Proteins; Biological Markers; Cell Adhesion Molecules/classification; Cell Adhesion Molecules/metabolism; Chick Embryo; Coronary Vessels/embryology; Membrane Proteins/classification; Membrane Proteins/metabolism; Mesoderm; Mice; Muscle Proteins/classification; Muscle Proteins/metabolism; Pericardium/metabolism; Rabbits; Rats; Subcellular Fractions

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CHICK:POPD1

located_in

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:POPD1

involved_in

GO:0003201: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:POPD1

located_in

GO:0071944: cell periphery

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002348)
  • part_of:(UBERON:0000483)|part_of:(UBERON:0007239)

Seeded From UniProt

complete

CHICK:POPD1

located_in

GO:0089717: spanning component of membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:POPD1

involved_in

GO:0090132: epithelium migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:POPD1

part_of

GO:0071944: cell periphery

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002348)
  • part_of:(UBERON:0000483)|part_of:(UBERON:0007239)

Seeded From UniProt

complete

CHICK:POPD1

part_of

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:POPD1

part_of

GO:0089717: spanning component of membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:POPD1

involved_in

GO:0090132: epithelium migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:POPD1

involved_in

GO:0003201: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:Q9DG21

part_of

GO:0071944: cell periphery

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002348)
  • part_of:(UBERON:0000483)|part_of:(UBERON:0007239)

Seeded From UniProt

complete

CHICK:Q9DG21

part_of

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q9DG21

part_of

GO:0089717: spanning component of membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q9DG21

involved_in

GO:0090132: epithelium migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:Q9DG21

involved_in

GO:0003201: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:Q9DG22

part_of

GO:0071944: cell periphery

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002348)
  • part_of:(UBERON:0000483)|part_of:(UBERON:0007239)

Seeded From UniProt

complete

CHICK:Q9DG22

part_of

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q9DG22

part_of

GO:0089717: spanning component of membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q9DG22

involved_in

GO:0090132: epithelium migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:Q9DG22

involved_in

GO:0003201: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:Q9DG23

part_of

GO:0071944: cell periphery

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002348)
  • part_of:(UBERON:0000483)|part_of:(UBERON:0007239)

Seeded From UniProt

complete

CHICK:Q9DG23

part_of

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q9DG23

part_of

GO:0089717: spanning component of membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q9DG23

involved_in

GO:0090132: epithelium migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:Q9DG23

involved_in

GO:0003201: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:Q9PWC0

part_of

GO:0071944: cell periphery

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002348)
  • part_of:(UBERON:0000483)|part_of:(UBERON:0007239)

Seeded From UniProt

complete

CHICK:Q9PWC0

part_of

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q9PWC0

part_of

GO:0089717: spanning component of membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CHICK:Q9PWC0

involved_in

GO:0090132: epithelium migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete

CHICK:Q9PWC0

involved_in

GO:0003201: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0004160)

Seeded From UniProt

complete


See also

References

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