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PMID:11483765

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Citation

Lane, BR, Lore, K, Bock, PJ, Andersson, J, Coffey, MJ, Strieter, RM and Markovitz, DM (2001) Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy. J. Virol. 75:8195-202

Abstract

Production of the C-X-C chemokines interleukin-8 (IL-8) and growth-regulated oncogene alpha (GRO-alpha) in macrophages is stimulated by exposure to human immunodeficiency virus type 1 (HIV-1). We have demonstrated previously that GRO-alpha then stimulates HIV-1 replication in both T lymphocytes and macrophages. Here we demonstrate that IL-8 also stimulates HIV-1 replication in macrophages and T lymphocytes. We further show that increased levels of IL-8 are present in the lymphoid tissue of patients with AIDS. In addition, we demonstrate that compounds which inhibit the actions of IL-8 and GRO-alpha via their receptors, CXCR1 and CXCR2, also inhibit HIV-1 replication in both T lymphocytes and macrophages, indicating potential therapeutic uses for these compounds in HIV-1 infection and AIDS.

Links

PubMed PMC115064

Keywords

Acquired Immunodeficiency Syndrome/immunology; Acquired Immunodeficiency Syndrome/virology; Antibodies/immunology; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors/antagonists & inhibitors; Chemotactic Factors/pharmacology; Growth Substances/pharmacology; HIV-1/drug effects; HIV-1/physiology; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-8/antagonists & inhibitors; Interleukin-8/immunology; Interleukin-8/metabolism; Interleukin-8/pharmacology; Lymphoid Tissue/immunology; Lymphoid Tissue/metabolism; Macrophages/virology; Monocytes; Phenylurea Compounds/pharmacology; Receptors, Interleukin-8A/immunology; Receptors, Interleukin-8B/immunology; T-Lymphocytes/virology; Virus Replication/drug effects

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:IL8

involved_in

GO:0006954: inflammatory response

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IL8

involved_in

GO:0006954: inflammatory response

ECO:0000304: author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

HUMAN:IL8

involved_in

GO:0042119: neutrophil activation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IL8

involved_in

GO:0001525: angiogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IL8

involved_in

GO:0045091: regulation of single stranded viral RNA replication via double stranded DNA intermediate

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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