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PMID:11483432

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Citation

Ardell, DH and Andersen, SO (2001) Tentative identification of a resilin gene in Drosophila melanogaster. Insect Biochem. Mol. Biol. 31:965-70

Abstract

A search of the Drosophila genome for gene products with similarities to the amino acid sequences of three tryptic peptides from locust (Schistocerca gregaria) resilin gave two positive results: gene products CG15920 and CG9036. In both conceptual translation products a 62-residue region is present, which is identical to the resilin peptides in 29 positions. Gene product CG15920 has an amino acid composition closely resembling that of resilins from various insect species, and it has an N-terminal signal peptide sequence indicating that it is an extracellular protein. The 62-residue region shows similarity to the RR-2 sequence, which is common for a number of matrix proteins from insect solid cuticle. The N- and C-terminal regions flanking the 62-residue in CG15920 are dominated by 18 repeats of a 15-residue sequence and 11 repeats of a 13-residue sequence, respectively. The structures of the repeats predict that the peptide chain will fold in an irregular, extended beta-spiral, resembling the structures suggested for mammalian elastin and spider flagelliform silk, two materials which, like resilin, possess long-range elasticity. Accordingly, we suggest that gene product CG15920 is a Drosophila resilin precursor.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Drosophila melanogaster/genetics; Genes, Insect; Insect Proteins/genetics; Molecular Sequence Data; Sequence Homology, Amino Acid

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:RESIL

located_in

GO:0005576: extracellular region

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

DROME:RESIL

part_of

GO:0005576: extracellular region

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

DROME:RESIL

enables

GO:0030023: extracellular matrix constituent conferring elasticity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

DROME:RESIL

enables

GO:0042302: structural constituent of cuticle

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete


See also

References

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