PMID:11455422

Citation	Zhu, W, Foehr, M, Jaynes, JB and Hanes, SD (2001) Drosophila SAP18, a member of the Sin3/Rpd3 histone deacetylase complex, interacts with Bicoid and inhibits its activity. Dev. Genes Evol. 211:109-17
Abstract	Bicoid directs anterior development in Drosophila embryos by activating different genes along the anterior-posterior axis. However, its activity is down-regulated at the anterior tip of the embryo, in a process known as retraction. Retraction is under the control of the terminal polarity system, and results in localized repression of Bicoid target genes. Here, we describe a Drosophila homolog of human SAP18, a member of the Sin3A/Rpd3 histone deacetylase complex. dSAP18 interacts with Bicoid in yeast and in vitro, and is expressed early in development coincident with Bicoid. In tissue culture cells, dSAP18 inhibits the ability of Bicoid to activate reporter genes. These results suggest a model in which dSAP18 interacts with Bicoid to silence expression of Bicoid target genes in the anterior tip of the embryo.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Chromosome Mapping; DNA; Drosophila/embryology; Drosophila Proteins; Gene Expression Regulation, Developmental; Histone Deacetylases/metabolism; Homeodomain Proteins/antagonists & inhibitors; Homeodomain Proteins/metabolism; Humans; Molecular Sequence Data; Protein Binding; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Trans-Activators/antagonists & inhibitors; Trans-Activators/metabolism; Transcription Factors/chemistry; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic
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