GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:11244088

From GONUTS
Jump to: navigation, search
Citation

Wooten, MW, Seibenhener, ML, Mamidipudi, V, Diaz-Meco, MT, Barker, PA and Moscat, J (2001) The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J. Biol. Chem. 276:7709-12

Abstract

Nerve growth factor (NGF) binding to both p75 and TrkA neurotrophin receptors activates the transcription factor nuclear factor kappaB (NF-kappaB). Here we show that the atypical protein kinase C-interacting protein, p62, which binds TRAF6, selectively interacts with TrkA but not p75. In contrast, TRAF6 interacts with p75 but not TrkA. We demonstrate the formation of a TRAF6-p62 complex that serves as a bridge linking both p75 and TrkA signaling. Of functional relevance, transfection of antisense p62-enhanced p75-mediated cell death and diminished NGF-induced differentiation occur through a mechanism involving inhibition of IKK activity. These findings reveal a new function for p62 as a common platform for communication of both p75-TRAF6 and TrkA signals. Moreover, we demonstrated that p62 serves as a scaffold for activation of the NF-kappaB pathway, which mediates NGF survival and differentiation responses.

Links

PubMed Online version:10.1074/jbc.C000869200

Keywords

Animals; Carrier Proteins/physiology; Cells, Cultured; Humans; NF-kappa B/metabolism; Nerve Growth Factor/physiology; PC12 Cells; Protein Kinase C/metabolism; Rats; Receptor, Nerve Growth Factor/physiology; Receptor, trkA/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:TNR1B

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P37198

F

Seeded From UniProt

complete

HUMAN:NUP62

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P20333

F

Seeded From UniProt

complete

HUMAN:NUP62

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Y4K3

F

Seeded From UniProt

complete

HUMAN:NUP62

enables

GO:0030159: signaling receptor complex adaptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:NUP62

involved_in

GO:0008219: cell death

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NUP62

involved_in

GO:0045742: positive regulation of epidermal growth factor receptor signaling pathway

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NUP62

involved_in

GO:0043069: negative regulation of programmed cell death

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TRAF6

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P37198

F

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.