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PMID:11063687

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Citation

Eisenmann, DM and Kim, SK (2000) Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development. Genetics 156:1097-116

Abstract

The Caenorhabditis elegans vulva develops from the progeny of three vulval precursor cells (VPCs) induced to divide and differentiate by a signal from the somatic gonad. Evolutionarily conserved Ras and Notch extracellular signaling pathways are known to function during this process. To identify novel loci acting in vulval development, we carried out a genetic screen for mutants having a protruding-vulva (Pvl) mutant phenotype. Here we report the initial genetic characterization of several novel loci: bar-1, pvl-4, pvl-5, and pvl-6. In addition, on the basis of their Pvl phenotypes, we show that the previously identified genes lin-26, mom-3/mig-14, egl-18, and sem-4 also function during vulval development. Our characterization indicates that (1) pvl-4 and pvl-5 are required for generation/survival of the VPCs; (2) bar-1, mom-3/mig-14, egl-18, and sem-4 play a role in VPC fate specification; (3) lin-26 is required for proper VPC fate execution; and (4) pvl-6 acts during vulval morphogenesis. In addition, two of these genes, bar-1 and mom-3/mig-14, are known to function in processes regulated by Wnt signaling, suggesting that a Wnt signaling pathway is acting during vulval development.

Links

PubMed PMC1461321

Keywords

Animals; Caenorhabditis elegans/anatomy & histology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Chromosome Mapping; Disorders of Sex Development; Ethyl Methanesulfonate; Female; Gene Expression Regulation, Developmental; Genes, Helminth; Heterozygote; Male; Mutagenesis; Phenotype; Proto-Oncogene Proteins/genetics; Recombination, Genetic; Signal Transduction; Vulva/anatomy & histology; Vulva/cytology; Vulva/growth & development; Wnt Proteins; Zebrafish Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:BAR1

involved_in

GO:0007617: mating behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00145412

P

Seeded From UniProt

complete

CAEEL:BAR1

involved_in

GO:0007265: Ras protein signal transduction

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00002335

P

Seeded From UniProt

complete

CAEEL:BAR1

involved_in

GO:0030334: regulation of cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00145412

P

Seeded From UniProt

complete

CAEEL:BAR1

involved_in

GO:0040028: regulation of vulval development

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00145412

P

Seeded From UniProt

complete

CAEEL:BAR1

involved_in

GO:0040028: regulation of vulval development

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001186

P

Seeded From UniProt

complete

CAEEL:BAR1

involved_in

GO:0040028: regulation of vulval development

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00004773

P

Seeded From UniProt

complete

CAEEL:BAR1

involved_in

GO:0018991: oviposition

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00145412

P

Seeded From UniProt

complete

CAEEL:BAR1

involved_in

GO:0042659: regulation of cell fate specification

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00145412

P

Seeded From UniProt

complete

CAEEL:BAR1

involved_in

GO:0043058: regulation of backward locomotion

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00145412

P

Seeded From UniProt

complete


See also

References

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