PMID:11063687

Citation	Eisenmann, DM and Kim, SK (2000) Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development. Genetics 156:1097-116
Abstract	The Caenorhabditis elegans vulva develops from the progeny of three vulval precursor cells (VPCs) induced to divide and differentiate by a signal from the somatic gonad. Evolutionarily conserved Ras and Notch extracellular signaling pathways are known to function during this process. To identify novel loci acting in vulval development, we carried out a genetic screen for mutants having a protruding-vulva (Pvl) mutant phenotype. Here we report the initial genetic characterization of several novel loci: bar-1, pvl-4, pvl-5, and pvl-6. In addition, on the basis of their Pvl phenotypes, we show that the previously identified genes lin-26, mom-3/mig-14, egl-18, and sem-4 also function during vulval development. Our characterization indicates that (1) pvl-4 and pvl-5 are required for generation/survival of the VPCs; (2) bar-1, mom-3/mig-14, egl-18, and sem-4 play a role in VPC fate specification; (3) lin-26 is required for proper VPC fate execution; and (4) pvl-6 acts during vulval morphogenesis. In addition, two of these genes, bar-1 and mom-3/mig-14, are known to function in processes regulated by Wnt signaling, suggesting that a Wnt signaling pathway is acting during vulval development.
Links	PubMed PMC1461321
Keywords	Animals; Caenorhabditis elegans/anatomy & histology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Chromosome Mapping; Disorders of Sex Development; Ethyl Methanesulfonate; Female; Gene Expression Regulation, Developmental; Genes, Helminth; Heterozygote; Male; Mutagenesis; Phenotype; Proto-Oncogene Proteins/genetics; Recombination, Genetic; Signal Transduction; Vulva/anatomy & histology; Vulva/cytology; Vulva/growth & development; Wnt Proteins; Zebrafish Proteins
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
CAEEL:BAR1	involved_in	GO:0007617: mating behavior	ECO:0000315: mutant phenotype evidence used in manual assertion	WB:WBVar00145412	P		Seeded From UniProt	complete
CAEEL:BAR1	involved_in	GO:0007265: Ras protein signal transduction	ECO:0000316: genetic interaction evidence used in manual assertion	WB:WBGene00002335	P		Seeded From UniProt	complete
CAEEL:BAR1	involved_in	GO:0030334: regulation of cell migration	ECO:0000315: mutant phenotype evidence used in manual assertion	WB:WBVar00145412	P		Seeded From UniProt	complete
CAEEL:BAR1	involved_in	GO:0040028: regulation of vulval development	ECO:0000315: mutant phenotype evidence used in manual assertion	WB:WBVar00145412	P		Seeded From UniProt	complete
CAEEL:BAR1	involved_in	GO:0040028: regulation of vulval development	ECO:0000316: genetic interaction evidence used in manual assertion	WB:WBGene00001186	P		Seeded From UniProt	complete
CAEEL:BAR1	involved_in	GO:0040028: regulation of vulval development	ECO:0000316: genetic interaction evidence used in manual assertion	WB:WBGene00004773	P		Seeded From UniProt	complete
CAEEL:BAR1	involved_in	GO:0018991: oviposition	ECO:0000315: mutant phenotype evidence used in manual assertion	WB:WBVar00145412	P		Seeded From UniProt	complete
CAEEL:BAR1	involved_in	GO:0042659: regulation of cell fate specification	ECO:0000315: mutant phenotype evidence used in manual assertion	WB:WBVar00145412	P		Seeded From UniProt	complete
CAEEL:BAR1	involved_in	GO:0043058: regulation of backward locomotion	ECO:0000315: mutant phenotype evidence used in manual assertion	WB:WBVar00145412	P		Seeded From UniProt	complete

References

See Help:References for how to manage references in GONUTS.