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PMID:10996790

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Citation

Michaux, G, Gansmuller, A, Hindelang, C and Labouesse, M (2000) CHE-14, a protein with a sterol-sensing domain, is required for apical sorting in C. elegans ectodermal epithelial cells. Curr. Biol. 10:1098-107

Abstract

Polarised trafficking of proteins is critical for normal expression of the epithelial phenotype, but its genetic control is not understood. The regulatory gene lin-26 is essential for normal epithelial differentiation in the nematode Caenorhabditis elegans. To identify potential effectors of lin-26, we characterised mutations that result in lin-26-like phenotypes. Here, we report the phenotypic and molecular analysis of one such mutant line, che-14.

Links

PubMed

Keywords

Amino Acid Motifs; Animals; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism; Caenorhabditis elegans/ultrastructure; Caenorhabditis elegans Proteins; Cell Polarity; Cytoplasmic Vesicles/metabolism; Cytoplasmic Vesicles/ultrastructure; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Ectoderm/cytology; Ectoderm/metabolism; Epithelial Cells/cytology; Epithelial Cells/metabolism; Exocytosis; Helminth Proteins/chemistry; Helminth Proteins/genetics; Helminth Proteins/physiology; Microscopy, Electron; Microscopy, Phase-Contrast; Neurons/cytology; Neurons/ultrastructure; Phenotype; Plasmids/genetics; Protein Transport; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Sequence Deletion/genetics; Sterols/metabolism; Transcription Factors/genetics; Transcription Factors/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:G5EEW0

located_in

GO:0016324: apical plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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