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PMID:10965141

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Citation

Sims, MA, Field, SD, Barnes, MR, Shaikh, N, Ellington, K, Murphy, KE, Spurr, N and Campbell, DA (2000) Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51. Cytogenet. Cell Genet. 89:268-71

Abstract

The integrin family of receptors serves as major receptors for extracellular matrix-mediated cell adhesion and migration, cytoskeletal organisation, cell proliferation, survival, and differentiation. The alpha-V integrins consist of a subset which share a common alpha-V subunit combined with one of five beta subunits (beta-1, 3, 5, 6, or 8). The alpha-V integrins have been implicated in a number of developmental processes, including vasculogenesis and angiogenesis, and are therapeutic targets for inhibition of angiogenesis and osteoporosis. The human cDNA for alpha-V integrin (ITGAV) consists of a 5,717-bp transcript with a coding sequence (CDS) of 3,146 bp encoding a 150-kDa mature peptide. Here we describe the gene structure of ITGAV.

Links

PubMed Online version:15631

Keywords

Antigens, CD/genetics; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 2/genetics; Cloning, Molecular; DNA/chemistry; DNA/genetics; Exons; Genes/genetics; Humans; Integrin alphaV; Introns; Molecular Sequence Data; Sequence Analysis, DNA; Sequence Tagged Sites

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:ITAV

involved_in

GO:0007160: cell-matrix adhesion

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ITAV

part_of

GO:0034683: integrin alphav-beta3 complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete


See also

References

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