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PMID:10806425

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Citation

Soushko, M and Mitchell, AP (2000) An RNA-binding protein homologue that promotes sporulation-specific gene expression in Saccharomyces cerevisiae. Yeast 16:631-9

Abstract

Prior studies have shown that S. cerevisiae rim4 mutations cause reduced expression of a sporulation-specific reporter gene and sporulation. We report here that RIM4 (ORF YHL024W) is a putative RNA-binding protein of the RRM class that is expressed at elevated levels early in meiosis. Mutations in the two RRMs reduce or abolish sporulation and, in some cases, cause reduced Rim4p expression. RIM4 is required for expression of early and middle sporulation-specific genes. Unlike other meiotic regulatory genes, RIM4 is required for full gene activation through both the Ime1p and Ime2p pathways. The rim4Delta defect in activation by Ime2p is suppressed by a hyperactive Ime2p derivative. These observations argue that Rim4p may act upstream of Ime2p, perhaps in a nutritional sensing pathway.

Links

PubMed Online version:<631::AID-YEA559>3.0.CO;2-U 10.1002/(SICI)1097-0061(200005)16:7<631::AID-YEA559>3.0.CO;2-U

Keywords

Cell Cycle Proteins; Fungal Proteins/genetics; Fungal Proteins/metabolism; Gene Expression Regulation, Fungal; Intracellular Signaling Peptides and Proteins; Meiosis; Protein Kinases/genetics; Protein Kinases/metabolism; Protein-Serine-Threonine Kinases; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae/physiology; Saccharomyces cerevisiae Proteins; Spores, Fungal/genetics; Spores, Fungal/physiology; Transcription, Genetic; Transcriptional Activation

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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