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PMID:10733527
| Citation |
Brodsky, MH, Sekelsky, JJ, Tsang, G, Hawley, RS and Rubin, GM (2000) mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development. Genes Dev. 14:666-78 |
|---|---|
| Abstract |
Checkpoints block cell cycle progression in eukaryotic cells exposed to DNA damaging agents. We show that several Drosophila homologs of checkpoint genes, mei-41, grapes, and 14-3-3epsilon, regulate a DNA damage checkpoint in the developing eye. We have used this assay to show that the mutagen-sensitive gene mus304 is also required for this checkpoint. mus304 encodes a novel coiled-coil domain protein, which is targeted to the cytoplasm. Similar to mei-41, mus304 is required for chromosome break repair and for genomic stability. mus304 animals also exhibit three developmental defects, abnormal bristle morphology, decreased meiotic recombination, and arrested embryonic development. We suggest that these phenotypes reflect distinct developmental consequences of a single underlying checkpoint defect. Similar mechanisms may account for the puzzling array of symptoms observed in humans with mutations in the ATM tumor suppressor gene. |
| Links | |
| Keywords |
Animals; DNA Damage/genetics; DNA Repair/genetics; Drosophila/embryology; Embryo, Nonmammalian/abnormalities; Eye/cytology; Eye/embryology; Female; G2 Phase/genetics; Loss of Heterozygosity; Meiosis/genetics; Mitosis/genetics; Mutation |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
DROME:CHK1 |
involved_in |
GO:0000077: DNA damage checkpoint |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:1433E |
involved_in |
GO:0000077: DNA damage checkpoint |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:ATRIP |
part_of |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
DROME:ATRIP |
involved_in |
GO:0007348: regulation of syncytial blastoderm mitotic cell cycle |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:ATRIP |
involved_in |
GO:0006281: DNA repair |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:ATRIP |
involved_in |
GO:0000077: DNA damage checkpoint |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:ATRIP |
involved_in |
GO:0007143: female meiotic nuclear division |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:ATRIP |
involved_in |
GO:0016321: female meiosis chromosome segregation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:ATRIP |
involved_in |
GO:0007131: reciprocal meiotic recombination |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:ATR |
involved_in |
GO:0007348: regulation of syncytial blastoderm mitotic cell cycle |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
DROME:ATR |
involved_in |
GO:0000077: DNA damage checkpoint |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
See also
References
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