GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10716995
| Citation |
Dent, JA, Smith, MM, Vassilatis, DK and Avery, L (2000) The genetics of ivermectin resistance in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 97:2674-9 |
|---|---|
| Abstract |
The ability of organisms to evolve resistance threatens the effectiveness of every antibiotic drug. We show that in the nematode Caenorhabditis elegans, simultaneous mutation of three genes, avr-14, avr-15, and glc-1, encoding glutamate-gated chloride channel (GluCl) alpha-type subunits confers high-level resistance to the antiparasitic drug ivermectin. In contrast, mutating any two channel genes confers modest or no resistance. We propose a model in which ivermectin sensitivity in C. elegans is mediated by genes affecting parallel genetic pathways defined by the family of GluCl genes. The sensitivity of these pathways is further modulated by unc-7, unc-9, and the Dyf (dye filling defective) genes, which alter the structure of the nervous system. Our results suggest that the evolution of drug resistance can be slowed by targeting antibiotic drugs to several members of a multigene family. |
| Links | |
| Keywords |
Animals; Antinematodal Agents/pharmacology; Caenorhabditis elegans/drug effects; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Chloride Channels/genetics; Cloning, Molecular; Drug Resistance/genetics; Electrophysiology; Glutamic Acid/pharmacology; Helminth Proteins/genetics; Ivermectin/pharmacology; Models, Biological; Models, Genetic; Mutation; Pharynx/drug effects; Protein Binding |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
CAEEL:Q8IFY7 |
located_in |
GO:0016020: membrane |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
CAEEL:Q8IFY7 |
involved_in |
GO:0006811: ion transport |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
CAEEL:Q8IFY7 |
enables |
GO:0008068: extracellularly glutamate-gated chloride channel activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
CAEEL:Q8IFY7 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q8IFY7 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q8IFY7 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q8IFY7 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q95Q96 |
located_in |
GO:0016020: membrane |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
CAEEL:Q95Q96 |
involved_in |
GO:0006811: ion transport |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
CAEEL:Q95Q96 |
enables |
GO:0008068: extracellularly glutamate-gated chloride channel activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
CAEEL:Q95Q96 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q95Q96 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q95Q96 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q95Q96 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q95Q97 |
located_in |
GO:0016020: membrane |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
CAEEL:Q95Q97 |
involved_in |
GO:0006811: ion transport |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
CAEEL:Q95Q97 |
enables |
GO:0008068: extracellularly glutamate-gated chloride channel activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
CAEEL:Q95Q97 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q95Q97 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q95Q97 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
|
CAEEL:Q95Q97 |
involved_in |
GO:0042493: response to drug |
ECO:0000316: genetic interaction evidence used in manual assertion |
WB:WBGene00000233 |
P |
Seeded From UniProt |
complete | |
See also
References
See Help:References for how to manage references in GONUTS.
