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PMID:10692383
| Citation |
Rosenberg, EY, Ma, D and Nikaido, H (2000) AcrD of Escherichia coli is an aminoglycoside efflux pump. J. Bacteriol. 182:1754-6 |
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| Abstract |
AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain. |
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| Keywords |
Aminoglycosides; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Carrier Proteins/genetics; Carrier Proteins/metabolism; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/growth & development; Escherichia coli/metabolism; Gene Deletion; Microbial Sensitivity Tests |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
ECOLI:ACRD |
acts_upstream_of_or_within |
GO:0042908: xenobiotic transport |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
ECOLI:ACRD |
acts_upstream_of_or_within |
GO:0046677: response to antibiotic |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
See also
References
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