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PMID:10692383

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Citation

Rosenberg, EY, Ma, D and Nikaido, H (2000) AcrD of Escherichia coli is an aminoglycoside efflux pump. J. Bacteriol. 182:1754-6

Abstract

AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain.

Links

PubMed PMC94475

Keywords

Aminoglycosides; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Carrier Proteins/genetics; Carrier Proteins/metabolism; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/growth & development; Escherichia coli/metabolism; Gene Deletion; Microbial Sensitivity Tests

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ECOLI:ACRD

acts_upstream_of_or_within

GO:0042908: xenobiotic transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:ACRD

acts_upstream_of_or_within

GO:0046677: response to antibiotic

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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