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PMID:10625334
| Citation |
Schachner, M and Bartsch, U (2000) Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin. Glia 29:154-65 |
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| Abstract |
The myelin-associated glycoprotein, a minor component of myelin in the central and peripheral nervous system, has been implicated in the formation and maintenance of myelin. Although the analysis of MAG null mutants confirms this view, the phenotype of this mutant is surprisingly subtle. In the CNS of MAG-deficient mice, initiation of myelination, formation of morphologically intact myelin sheaths and to a minor extent, integrity of myelin is affected. In the PNS, in comparison, only maintenance of myelin is impaired. Recently, the large isoform of MAG has been identified as the functionally important isoform in the CNS, whereas the small MAG isoform is sufficient to maintain the integrity of myelinated fibers in the PNS. Remarkably, none of the different defects in the MAG mutant is consistently associated with each myelinated fiber. These observations suggest that other molecules performing similar functions as MAG might compensate, at least partially, for the absence of MAG in the null mutant. |
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| Keywords |
Animals; Central Nervous System/cytology; Central Nervous System/metabolism; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Myelin Sheath/metabolism; Myelin Sheath/physiology; Myelin Sheath/ultrastructure; Myelin-Associated Glycoprotein/genetics; Myelin-Associated Glycoprotein/physiology; Peripheral Nervous System/cytology; Peripheral Nervous System/metabolism; Phenotype; Protein Isoforms; Signal Transduction/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0031643: positive regulation of myelination |
ECO:0000315: |
P |
Fig 2b initiation of myelination is impaired in optic nerves of MAG-deficient mice |
complete | ||||
|
involved_in |
GO:0031643: positive regulation of myelination |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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