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PMID:10572052

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Citation

Quaggin, SE, Schwartz, L, Cui, S, Igarashi, P, Deimling, J, Post, M and Rossant, J (1999) The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Development 126:5771-83

Abstract

Epithelial-mesenchymal interactions are required for the development of all solid organs but few molecular mechanisms that underlie these interactions have been identified. Pod1 is a basic-helix-loop-helix (bHLH) transcription factor that is highly expressed in the mesenchyme of developing organs that include the lung, kidney, gut and heart and in glomerular visceral epithelial cells (podocytes). To determine the function of Pod1 in vivo, we have generated a lacZ-expressing null Pod1 allele. Null mutant mice are born but die in the perinatal period with severely hypoplastic lungs and kidneys that lack alveoli and mature glomeruli. Although Pod1 is exclusively expressed in the mesenchyme and podocytes, major defects are observed in the adjacent epithelia and include abnormalities in epithelial differentiation and branching morphogenesis. Pod1 therefore appears to be essential for regulating properties of the mesenchyme that are critically important for lung and kidney morphogenesis. Defects specific to later specialized cell types where Pod1 is expressed, such as the podocytes, were also observed, suggesting that this transcription factor may play multiple roles in kidney morphogenesis.

Links

PubMed

Keywords

Alleles; Animals; Basic Helix-Loop-Helix Transcription Factors; Embryonic and Fetal Development; Epithelium/physiology; Gene Expression; Helix-Loop-Helix Motifs; Kidney/embryology; Kidney Glomerulus/embryology; Lac Operon; Lung/embryology; Mesoderm/physiology; Mice; Mice, Mutant Strains; Morphogenesis; Transcription Factors/genetics; Transcription Factors/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:TCF21

acts_upstream_of_or_within

GO:0001944: vasculature development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0001822: kidney development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0001763: morphogenesis of a branching structure

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0001658: branching involved in ureteric bud morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0001657: ureteric bud development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0032835: glomerulus development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0007530: sex determination

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0030855: epithelial cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0048608: reproductive structure development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0048286: lung alveolus development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0060541: respiratory system development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0060435: bronchiole development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0060426: lung vasculature development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete

MOUSE:TCF21

acts_upstream_of_or_within

GO:0060425: lung morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2148207

P

Seeded From UniProt

complete


See also

References

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