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PMID:10520994
| Citation |
Takahashi, T, Fournier, A, Nakamura, F, Wang, LH, Murakami, Y, Kalb, RG, Fujisawa, H and Strittmatter, SM (1999) Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 99:59-69 |
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| Abstract |
Class 1 and 3 semaphorins repulse axons but bind to different cell surface proteins. We find that the two known semaphorin-binding proteins, plexin 1 (Plex 1) and neuropilin-1 (NP-1), form a stable complex. Plex 1 alone does not bind semaphorin-3A (Sema3A), but the NP-1/Plex 1 complex has a higher affinity for Sema3A than does NP-1 alone. While Sema3A binding to NP-1 does not alter nonneuronal cell morphology, Sema3A interaction with NP-1/Plex 1 complexes induces adherent cells to round up. Expression of a dominant-negative Plex 1 in sensory neurons blocks Sema3A-induced growth cone collapse. Sema3A treatment leads to the redistribution of growth cone NP-1 and plexin into clusters. Thus, physiologic Sema3A receptors consist of NP-1/plexin complexes. |
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| Keywords |
Animals; COS Cells; Ganglia, Spinal/cytology; Gene Expression/physiology; Growth Cones/chemistry; Growth Cones/metabolism; Humans; Kidney/cytology; Multigene Family; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neurons/chemistry; Neurons/cytology; Neurons/ultrastructure; Neuropilin-1; Protein Binding/physiology; Protein Structure, Tertiary; Receptors, Cell Surface/chemistry; Receptors, Cell Surface/genetics; Receptors, Cell Surface/metabolism; Signal Transduction/physiology; Solubility; Transfection |
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