GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:10081969

From GONUTS
Jump to: navigation, search
Citation

Tanahashi, H and Tabira, T (1999) Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein. Neurosci. Lett. 261:143-6

Abstract

We report the cDNA sequence of human Fe65L2. The human Fe65L2 encoded 486 amino acids; the deduced amino acid sequence was shorter by 18 amino acids than the rat protein and had 86% identity to the rat protein Three protein-protein interaction domains, a WW and two PID/PTB elements, were conserved among the Fe65 protein family. Human Fe65L2 mRNA was expressed in various tissues; a transcript of about 2.2 kb was mainly expressed in the brain. A splicing variant lacking two amino acids in the first PID/PTB element was detected. We also confirmed that the carboxyl-terminal region of PID/PTB of the Fe65L2 interacted with the intracellular domain of the Alzheimer's beta-amyloid precursor protein (APP) and APP-like proteins.

Links

PubMed

Keywords

Alzheimer Disease/metabolism; Amino Acid Sequence; Amyloid beta-Protein Precursor/biosynthesis; Amyloid beta-Protein Precursor/metabolism; Animals; Base Sequence; Blotting, Northern; Carrier Proteins/biosynthesis; Carrier Proteins/metabolism; Cloning, Molecular; DNA, Complementary/biosynthesis; Humans; Molecular Sequence Data; Phosphoproteins/biosynthesis; Phosphoproteins/metabolism; RNA, Messenger/biosynthesis; Rats

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:APBB3

located_in

GO:0005737: cytoplasm

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:APBB3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P05067

F

Seeded From UniProt

complete

HUMAN:A4

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:O95704

F

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.