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PMID:10068647

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Citation

Hobert, O, Tessmar, K and Ruvkun, G (1999) The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development 126:1547-62

Abstract

We describe here the functional analysis of the C. elegans LIM homeobox gene lim-6, the ortholog of the mammalian Lmx-1a and b genes that regulate limb, CNS, kidney and eye development. lim-6 is expressed in a small number of sensory-, inter- and motorneurons, in epithelial cells of the uterus and in the excretory system. Loss of lim-6 function affects late events in the differentiation of two classes of GABAergic motorneurons which control rhythmic enteric muscle contraction. lim-6 is required to specify the correct axon morphology of these neurons and also regulates expression of glutamic acid decarboxylase, the rate limiting enzyme of GABA synthesis in these neurons. Moreover, lim-6 gene activity and GABA signaling regulate neuroendocrine outputs of the nervous system. In the chemosensory system lim-6 regulates the asymmetric expression of a probable chemosensory receptor. lim-6 is also required in epithelial cells for uterine morphogenesis. We compare the function of lim-6 to those of other LIM homeobox genes in C. elegans and suggest that LIM homeobox genes share the common theme of controlling terminal neural differentiation steps that when disrupted lead to specific neuroanatomical and neural function defects.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Animals, Genetically Modified; Caenorhabditis elegans/embryology; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Cell Differentiation; Female; Gene Expression Regulation, Developmental/genetics; Gene Expression Regulation, Enzymologic/genetics; Genes, Helminth; Genes, Homeobox/genetics; Genes, Reporter; Glutamate Decarboxylase/genetics; Homeodomain Proteins/genetics; LIM-Homeodomain Proteins; Molecular Sequence Data; Mutation; Nervous System/embryology; Neurites/metabolism; Sequence Homology, Amino Acid; Transcription Factors; gamma-Aminobutyric Acid/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:G4RV72

involved_in

GO:0030182: neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:G4RV72

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:G4RV72

involved_in

GO:0030421: defecation

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:G4RV72

involved_in

GO:0010468: regulation of gene expression

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:G4RV72

involved_in

GO:0009449: gamma-aminobutyric acid biosynthetic process

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:G4RV72

involved_in

GO:0007409: axonogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:G4RV72

involved_in

GO:0061038: uterus morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:G4RV72

involved_in

GO:0060756: foraging behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:Q21192

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:Q21192

involved_in

GO:0030421: defecation

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:Q21192

involved_in

GO:0007409: axonogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:Q21192

enables

GO:0003700: DNA-binding transcription factor activity

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:O60663

F

Seeded From UniProt

complete

CAEEL:Q21192

involved_in

GO:0061038: uterus morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:Q21192

involved_in

GO:0060756: foraging behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

Seeded From UniProt

complete

CAEEL:Q21192

involved_in

GO:0048666: neuron development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • results_in_development_of:(WBbt:0005190)|results_in_development_of:(WBbt:0005837)

Seeded From UniProt

complete

CAEEL:Q21192

involved_in

GO:1904081: positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091396

P

  • has_input:(WB:WBGene00006762)
  • occurs_in:(WBbt:0004822)|has_input(WB:WBGene00006762)
  • occurs_in:(WBbt:0005045)|has_input(WB:WBGene00006762)
  • occurs_in:(WBbt:0003843)

Seeded From UniProt

complete


See also

References

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