GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:10049357
| Citation |
Nomura, T, Khan, MM, Kaul, SC, Dong, HD, Wadhwa, R, Colmenares, C, Kohno, I and Ishii, S (1999) Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev. 13:412-23 |
|---|---|
| Abstract |
The N-CoR/SMRT complex containing mSin3 and histone deacetylase (HDAC) mediates transcriptional repression by nuclear hormone receptors and Mad. The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC. c-Ski and its related gene product Sno are required for transcriptional repression by Mad and thyroid hormone receptor (TRbeta). The oncogenic form, v-Ski, which lacks the mSin3A-binding domain, acts in a dominant-negative fashion, and abrogates transcriptional repression by Mad and TRbeta. In ski-deficient mouse embryos, the ornithine decarboxylase gene, whose expression is normally repressed by Mad-Max, is expressed ectopically. These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex. The involvement of c-Ski in the HDAC complex indicates that the function of the HDAC complex is important for oncogenesis. |
| Links | |
| Keywords |
Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; DNA-Binding Proteins/genetics; Embryo, Mammalian/metabolism; Fluorescent Antibody Technique; Gene Expression Regulation/genetics; Histone Deacetylases/genetics; In Situ Hybridization; Mice; Mice, Knockout; Mutation/genetics; Nuclear Proteins/genetics; Nuclear Receptor Co-Repressor 1; Ornithine Decarboxylase/genetics; Protein Binding/genetics; Proto-Oncogene Proteins/genetics; Receptors, Thyroid Hormone/genetics; Repressor Proteins/genetics; Transcription, Genetic/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
HUMAN:NCOR1 |
located_in |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
HUMAN:NCOR1 |
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P12755 |
F |
|
Seeded From UniProt |
complete |
|
HUMAN:SKI |
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:O75376 |
F |
|
Seeded From UniProt |
complete |
|
HUMAN:SKI |
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:Q60974 |
F |
Seeded From UniProt |
complete | |
|
HUMAN:SKI |
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:Q96ST3 |
F |
Seeded From UniProt |
complete | |
|
HUMAN:SKIL |
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:Q60974 |
F |
Seeded From UniProt |
complete | |
|
MOUSE:SKI |
enables |
GO:0003714: transcription corepressor activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
MOUSE:SKI |
located_in |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
MOUSE:SKI |
acts_upstream_of_or_within |
GO:0000122: negative regulation of transcription by RNA polymerase II |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
PR:Q60698 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P12755 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P12757 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P12757-1 |
F |
Seeded From UniProt |
complete | ||
|
HUMAN:SIN3A |
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P12755 |
F |
Seeded From UniProt |
complete | |
See also
References
See Help:References for how to manage references in GONUTS.
