PLAFK:DRTS

Species (Taxon ID)	Plasmodium falciparum (isolate K1 / Thailand). (5839)
Gene Name(s)	No Information Provided.
Protein Name(s)	Bifunctional dihydrofolate reductase-thymidylate synthase DHFR-TS Dihydrofolate reductase Thymidylate synthase
External Links
UniProt	P13922
EMBL	M22159 J04643 J03772 J03028
PIR	A39975
PDB	1J3I 1J3J 1J3K 3DG8 3DGA
PDBsum	1J3I 1J3J 1J3K 3DG8 3DGA
ProteinModelPortal	P13922
SMR	P13922
ChEMBL	CHEMBL1939
DrugBank	DB01131 DB00205 DB01299
MoonProt	P13922
BRENDA	1.5.1.3 2.1.1.45
SABIO-RK	P13922
UniPathway	UPA00077
EvolutionaryTrace	P13922
GO	GO:0004146 GO:0004799 GO:0006231 GO:0006545 GO:0006730 GO:0046654
Gene3D	3.30.572.10 3.40.430.10
HAMAP	MF_00008
InterPro	IPR024072 IPR012262 IPR017925 IPR001796 IPR023451 IPR000398 IPR020940
Pfam	PF00186 PF00303
PIRSF	PIRSF000389
PRINTS	PR00108
SUPFAM	SSF53597 SSF55831
TIGRFAMs	TIGR03284
PROSITE	PS00075 PS51330 PS00091

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004799	thymidylate synthase activity	PMID:12704428	ECO:0000314			F		Panel B in Figure 2 establishes the activity of Thymidylate Synthase in Plasmodium falciparium dihydrofolate reductase-thymidylate synthase. Figure 2 shows the junction region of alpha helix as a docking element onto the DHFR-TS domain interface. The long-range electrostatic interactions are among the major forces attracting the negatively charged alpha helix of a TS domain to the surface groove lined with positively charged amino acids from the helices of the DHFR domain.	complete CACAO 11982
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR012262 InterPro:IPR017925	F		Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000398 InterPro:IPR012262 InterPro:IPR020940	F		Seeded From UniProt	complete
involved_in	GO:0006231	dTMP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000398 InterPro:IPR020940	P		Seeded From UniProt	complete
involved_in	GO:0006730	one-carbon metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012262	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001796 InterPro:IPR012262 InterPro:IPR017925	P		Seeded From UniProt	complete
enables	GO:0004146	dihydrofolate reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.1.3	F		Seeded From UniProt	complete
enables	GO:0004799	thymidylate synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.45	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0006730	one-carbon metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0554	P		Seeded From UniProt	complete
involved_in	GO:0009165	nucleotide biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0545	P		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F		Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00077	P		Seeded From UniProt	complete
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