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MYCTU:3BHS

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) No Information Provided.
Protein Name(s) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase

Cholesterol dehydrogenase 3-beta-hydroxy-Delta(5)-steroid dehydrogenase 3-beta-HSD 3BHSD 3-beta hydroxysterol dehydrogenase 3-beta-hydroxy-5-ene steroid dehydrogenase Progesterone reductase Steroid Delta-isomerase Delta-5-3-ketosteroid isomerase

External Links
UniProt P9WQP7
EMBL AL123456
PIR H70897
RefSeq NP_215622.1
WP_003405840.1
ProteinModelPortal P9WQP7
SMR P9WQP7
STRING 83332.Rv1106c
BindingDB P9WQP7
ChEMBL CHEMBL1744528
EnsemblBacteria CCP43859
GeneID 886004
KEGG mtu:Rv1106c
mtv:RVBD_1106c
TubercuList Rv1106c
KO K16045
OMA DNYSRTK
PhylomeDB P9WQP7
UniPathway UPA00062
PRO PR:P9WQP7
Proteomes UP000001584
GO GO:0005829
GO:0005886
GO:0003854
GO:0070403
GO:0004769
GO:0016042
GO:0006694
GO:0008202
Gene3D 3.40.50.720
InterPro IPR002225
IPR016040
Pfam PF01073

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005886

plasma membrane

PMID:14532352[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0070403

NAD+ binding

PMID:17630785[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008202

steroid metabolic process

PMID:17630785[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:17630785[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004769

steroid delta-isomerase activity

PMID:17630785[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003854

3-beta-hydroxy-delta5-steroid dehydrogenase activity

PMID:17630785[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030283

testosterone dehydrogenase [NAD(P)] activity

PMID:17630785[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000189861
PANTHER:PTN000041225

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000041225
SGD:S000003125

F

Seeded From UniProt

complete

enables

GO:0003854

3-beta-hydroxy-delta5-steroid dehydrogenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002225

F

Seeded From UniProt

complete

involved_in

GO:0006694

steroid biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002225

P

Seeded From UniProt

complete

enables

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002225

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002225

P

Seeded From UniProt

complete

enables

GO:0004769

steroid delta-isomerase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.3.3.1

F

Seeded From UniProt

complete

enables

GO:0003854

3-beta-hydroxy-delta5-steroid dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.145

F

Seeded From UniProt

complete

enables

GO:0102294

cholesterol dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.145

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

involved_in

GO:0016042

lipid catabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0442

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0008202

steroid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0753

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

involved_in

GO:0006694

steroid biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00062

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Yang, X et al. (2007) Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. Biochemistry 46 9058-67 PubMed GONUTS page
  3. 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page